FST and BEX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FST	BEX2
Description		follistatin	brain expressed X-linked 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding	Signaling Receptor Binding Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Positive Regulation Of Hair Follicle Development Cellular Response To Growth Factor Stimulus	Apoptotic Process Signal Transduction Negative Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Regulation Of Cell Cycle
Pathways		Antagonism of Activin by Follistatin
Drugs		D-Myo-Inositol-Hexasulphate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Central corneal thickness ( 32528159) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29235454 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533) Refractive error ( 32231278) Vaginal microbiome composition (community state type) ( 32723796)
Interacting Genes		14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587	92 interacting genes: AKAP9 AURKA BCAR3 BLZF1 BORCS6 BRMS1 CCDC197 CCDC57 CCDC85B CCDC88B CDR2 CEP70 COG4 CTAG1A CTAG1B CYSRT1 EXOC8 FGFR2 FSD2 FST GPRASP3 HSF2BP HSPB2 HSPB2-C11orf52 KLHL20 KNSTRN KRT15 KRT19 KRT27 KRT31 KRT34 KRT38 KRT39 KRT40 KRT6A KRT75 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-3 KRTAP4-12 KRTAP5-9 KRTAP6-2 KRTAP6-3 LCN2 LDOC1 LMO2 LZTS2 MAGEA11 MAGEA2 MAGEA2B MAGEA4 MDFI MIPOL1 MKRN3 MORN3 MRPL38 MSS51 MTUS2 NECAB2 NFKBID OIP5 OMP PIK3CA PLA2G10 PLEKHG4 PNMA1 PPM1D PRDM14 PTPN11 ROPN1L SERTAD3 SPRED1 SPRY3 SSX2IP SYCE1 TACC3 TRAF1 TRAF2 TRIM27 TRIM42 TRIM69 TRIM73 TRIP6 USHBP1 VHL VPS28 ZDHHC17 ZNF19
Entrez ID		10468	84707
HPRD ID		00641	06484
Ensembl ID		ENSG00000134363	ENSG00000133134
Uniprot IDs		P19883	Q9BXY8
PDB IDs		2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?		Inhibin A Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Growth Factor Activity Regulation Of Follicle-stimulating Hormone Secretion Hemoglobin Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of B Cell Differentiation Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Macrophage Differentiation Cytokine Activity Hemoglobin Metabolic Process Hormone Activity Regulation Of Macrophage Differentiation Signaling Receptor Binding Activin Receptor Signaling Pathway Negative Regulation Of B Cell Activation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Endodermal Cell Differentiation Regulation Of B Cell Differentiation Reproductive Structure Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Leukocyte Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Immune System Process Negative Regulation Of Cell Activation Semicircular Canal Formation Inhibin B Complex Ovarian Follicle Development Negative Regulation Of Myeloid Leukocyte Differentiation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hormone Secretion Erythrocyte Differentiation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Positive Regulation Of Ovulation Progesterone Secretion Thymidine Kinase Activity Cellular Detoxification Of Hydrogen Peroxide Negative Regulation Of Multicellular Organismal Process Neural Fold Elevation Formation Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Protein Binding Cytoskeleton Organization Supramolecular Fiber Organization Cytosol Morphogenesis Of An Epithelium Hair Follicle Morphogenesis Cytoskeleton Identical Protein Binding Epithelial Cell Differentiation Tissue Morphogenesis Negative Regulation Of Protein Acetylation Microtubule Organizing Center Anatomical Structure Morphogenesis Organelle Organization Keratinization
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