FST and BMP5

Number of citations of the paper that reports this interaction (PubMedID 11580864)
59

Data Source:
HPRD (in vivo)

		FST	BMP5
Description		follistatin	bone morphogenetic protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm	Extracellular Region Extracellular Space Vesicle
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding	Cytokine Activity Protein Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Positive Regulation Of Hair Follicle Development Cellular Response To Growth Factor Stimulus	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation Cell Differentiation BMP Signaling Pathway Male Genitalia Development Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Ear Development Positive Regulation Of Transcription By RNA Polymerase II Cell Development Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Cartilage Development Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Anterior Head Development Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process
Pathways		Antagonism of Activin by Follistatin
Drugs		D-Myo-Inositol-Hexasulphate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Central corneal thickness ( 32528159) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29235454 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533) Refractive error ( 32231278) Vaginal microbiome composition (community state type) ( 32723796)	Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 28869591 30598549) Lean body mass ( 28552196) Schizophrenia ( 34099189) Zinc levels ( 26025379)
Interacting Genes		14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587	5 interacting genes: BMPR1A CHRDL2 FST MEOX2 NOG
Entrez ID		10468	653
HPRD ID		00641	00210
Ensembl ID		ENSG00000134363	ENSG00000112175
Uniprot IDs		P19883	A8K694 M9VUD0 P22003
PDB IDs		2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?		Inhibin A Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Growth Factor Activity Regulation Of Follicle-stimulating Hormone Secretion Hemoglobin Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of B Cell Differentiation Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Macrophage Differentiation Cytokine Activity Hemoglobin Metabolic Process Hormone Activity Regulation Of Macrophage Differentiation Signaling Receptor Binding Activin Receptor Signaling Pathway Negative Regulation Of B Cell Activation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Endodermal Cell Differentiation Regulation Of B Cell Differentiation Reproductive Structure Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Leukocyte Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Immune System Process Negative Regulation Of Cell Activation Semicircular Canal Formation Inhibin B Complex Ovarian Follicle Development Negative Regulation Of Myeloid Leukocyte Differentiation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hormone Secretion Erythrocyte Differentiation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Positive Regulation Of Ovulation Progesterone Secretion Thymidine Kinase Activity Cellular Detoxification Of Hydrogen Peroxide Negative Regulation Of Multicellular Organismal Process Neural Fold Elevation Formation Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate	Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neural Plate Pattern Specification BMP Signaling Pathway Pattern Specification Process Ventricular Compact Myocardium Morphogenesis Cartilage Development Regulation Of BMP Signaling Pathway Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Somite Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Heart Trabecula Morphogenesis Epithelial Cell Proliferation BMP Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Animal Organ Formation Cellular Response To BMP Stimulus Pituitary Gland Development Endoderm Development Cellular Response To Growth Factor Stimulus Ventricular Septum Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation System Development Response To Growth Factor Negative Regulation Of Cell Migration Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Limb Development Embryonic Digit Morphogenesis Mesoderm Development Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Outflow Tract Morphogenesis Artery Morphogenesis Dorsal/ventral Pattern Formation Regulation Of Heart Growth Somatic Stem Cell Population Maintenance Negative Regulation Of BMP Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Roof Of Mouth Development Animal Organ Development Regulation Of Animal Organ Morphogenesis Regulation Of Neural Crest Cell Differentiation
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