FST and BMP5

Number of citations of the paper that reports this interaction (PMID 11580864)
12

Data Source:
HPRD (in vivo)

		FST	BMP5
Gene Name		follistatin	bone morphogenetic protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm	Cellular_component Extracellular Space Membrane-bounded Vesicle
	Molecular Function	Signal Transducer Activity Protein Binding Heparan Sulfate Proteoglycan Binding Activin Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development BMP Signaling Pathway Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of Hair Follicle Development	Skeletal System Development Ossification Type B Pancreatic Cell Development Pattern Specification Process Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process BMP Signaling Pathway Male Genitalia Development Negative Regulation Of Aldosterone Biosynthetic Process Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Cartilage Development SMAD Protein Signal Transduction Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cortisol Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication
Pathways		Antagonism of Activin by Follistatin Signaling by Activin
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BMP5 C8orf33 FN1 INHA INHBA INHBE MEST TK1 TXN	4 interactors: BMPR1A CHRDL2 FST NOG
Entrez ID		10468	653
HPRD ID		00641	00210
Ensembl ID		ENSG00000134363	ENSG00000112175
Uniprot IDs		P19883	B4E0Y4 M9VUD0 P22003
PDB IDs		2B0U 2P6A 3HH2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Protein Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of Gonadotropin Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Phosphorylation Negative Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Macrophage Differentiation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Hemoglobin Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Male Sex Differentiation Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of B Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Negative Regulation Of Interferon-gamma Production Endodermal Cell Differentiation Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of B Cell Activation Sex Differentiation Regulation Of Intracellular Signal Transduction Anatomical Structure Development Negative Regulation Of Lymphocyte Differentiation Cell Development Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Endoderm Formation Positive Regulation Of Metabolic Process Negative Regulation Of Hormone Secretion Negative Regulation Of Immune System Process Response To Stimulus Developmental Process Ovarian Follicle Development Negative Regulation Of Transport Fetal Process Involved In Parturition Negative Regulation Of Myeloid Cell Differentiation	BMP Signaling Pathway Skeletal System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of BMP Signaling Pathway Organ Formation Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pituitary Gland Development Pattern Specification Process Embryonic Digit Morphogenesis Regulation Of BMP Signaling Pathway Endoderm Development Mesoderm Formation Tissue Morphogenesis Diencephalon Development Mesoderm Morphogenesis Somite Development Developmental Process Involved In Reproduction Negative Regulation Of Cell Differentiation Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Development Dorsal/ventral Pattern Formation Neural Plate Mediolateral Regionalization Negative Regulation Of Cytokine Activity Paraxial Mesoderm Structural Organization Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Odontogenesis Regulation Of Signal Transduction Mesenchymal Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Mesoderm Development Stem Cell Maintenance Positive Regulation Of Epithelial Cell Proliferation Organ Development Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Limb Morphogenesis Regulation Of Organ Morphogenesis Epithelium Development Negative Regulation Of Signal Transduction Gastrulation Regulation Of Ossification Limb Development Mesenchyme Development
Tagcloud ?		activin anthropometric blocking consideration copyright correlate elisa eumenorrheic follicular follistatin gestation luteal menstrual nested periods permit phases postpartum preeclamptic pregnancy pregnant protected reserved rights sought subset throughout towards women	abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		activin anthropometric blocking consideration copyright correlate elisa eumenorrheic follicular follistatin gestation luteal menstrual nested periods permit phases postpartum preeclamptic pregnancy pregnant protected reserved rights sought subset throughout towards women	abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Intersection) ?