FST and INHBA

Number of citations of the paper that reports this interaction (PMID 16198295)
41

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		FST	INHBA
Gene Name		follistatin	inhibin, beta A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm	Extracellular Region Activin A Complex Inhibin A Complex
	Molecular Function	Signal Transducer Activity Protein Binding Heparan Sulfate Proteoglycan Binding Activin Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Type II Activin Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development BMP Signaling Pathway Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of Hair Follicle Development	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Endodermal Cell Differentiation Growth Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Palate Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Antagonism of Activin by Follistatin Signaling by Activin	Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis
Drugs
Diseases
GWAS			Menarche (age at onset) ( 21102462) Pit-and-Fissure caries ( 23470693) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		9 interactors: BMP5 C8orf33 FN1 INHA INHBA INHBE MEST TK1 TXN	13 interactors: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		10468	3624
HPRD ID		00641	00929
Ensembl ID		ENSG00000134363
Uniprot IDs		P19883	A4D1W7 P08476
PDB IDs		2B0U 2P6A 3HH2	1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Protein Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of Gonadotropin Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Phosphorylation Negative Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Macrophage Differentiation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Hemoglobin Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Male Sex Differentiation Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of B Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Negative Regulation Of Interferon-gamma Production Endodermal Cell Differentiation Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of B Cell Activation Sex Differentiation Regulation Of Intracellular Signal Transduction Anatomical Structure Development Negative Regulation Of Lymphocyte Differentiation Cell Development Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Endoderm Formation Positive Regulation Of Metabolic Process Negative Regulation Of Hormone Secretion Negative Regulation Of Immune System Process Response To Stimulus Developmental Process Ovarian Follicle Development Negative Regulation Of Transport Fetal Process Involved In Parturition Negative Regulation Of Myeloid Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Organ Development Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Development Of Primary Sexual Characteristics Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Sex Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Developmental Process System Development Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Signaling Multicellular Organismal Development Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of BMP Signaling Pathway Reproductive Process Gonad Development Regulation Of Phosphorus Metabolic Process Skeletal System Development Determination Of Left/right Symmetry Cell Surface Receptor Signaling Pathway Determination Of Bilateral Symmetry Regulation Of Cell Differentiation Development Of Primary Female Sexual Characteristics Tissue Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Single Organism Reproductive Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Bone Mineralization Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Biomineral Tissue Development Regulation Of Cellular Protein Metabolic Process Regulation Of Myeloid Cell Differentiation
Tagcloud ?		activin anthropometric blocking consideration copyright correlate elisa eumenorrheic follicular follistatin gestation luteal menstrual nested periods permit phases postpartum preeclamptic pregnancy pregnant protected reserved rights sought subset throughout towards women	acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis
Tagcloud (Difference) ?		activin anthropometric blocking consideration copyright correlate elisa eumenorrheic follicular follistatin gestation luteal menstrual nested periods permit phases postpartum preeclamptic pregnancy pregnant protected reserved rights sought subset throughout towards women	acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis
Tagcloud (Intersection) ?