IMPDH2 and RAD54L2

		IMPDH2	RAD54L2
Description		inosine monophosphate dehydrogenase 2	RAD54 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nuclear Body
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding	Nucleotide Binding DNA Binding Transcription Coregulator Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process	Chromatin Organization Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4	44 interacting genes: AR ATN1 ATXN1 ATXN1L BANP BHLHE40 CBX3 CRK FAM118B FXR2 HMG20A HNRNPCL1 HOMER1 IMPDH1 KIFC3 KRTAP6-3 LCE1D LCE1F NR3C1 NR5A1 NR5A2 PAICS PIAS1 POU1F1 PPARG PSMA3 RAD51 RBPMS RUNX1T1 RXRA SIAH1 SQSTM1 SUMO1 SUMO2 SUMO3 TAX1BP1 TFAP2D THAP1 TRAF2 TRAF4 UBE2I VCX ZBTB26 ZC2HC1A
Entrez ID		3615	23132
HPRD ID		00895	10018
Ensembl ID		ENSG00000178035	ENSG00000164080
Uniprot IDs		A0A7I2YQK5 E7ETK5 H0Y4R1 P12268	B3KV54 Q9Y4B4
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process	Identical Protein Binding Enzyme Binding PML Body Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nucleus Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Protein Sumoylation Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II 'de Novo' XMP Biosynthetic Process Presynaptic Cytosol Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Signaling Adaptor Activity Hormone-mediated Signaling Pathway Chromatin Regulation Of Primary Metabolic Process Chromatin Binding GMP Biosynthetic Process IMP Dehydrogenase Activity DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Protein Tag Activity Purine Ribonucleoside Monophosphate Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression SUMO Transferase Activity Sequence-specific DNA Binding Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process
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