TNFRSF9 and IDH3B

Data Source: HiPPIP (Novel)

		TNFRSF9	IDH3B
Name		TNF receptor superfamily member 9	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)
	Molecular Function	Protein Binding Signaling Receptor Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NAD Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation	Tricarboxylic Acid Cycle Isocitrate Metabolic Process
Pathways		TNFs bind their physiological receptors	Citric acid cycle (TCA cycle)
Drugs		Urelumab	NADH
Diseases		None	Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825 ) Celiac disease ( 20190752 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 28067908 ) Psoriasis ( 23143594 25903422 ) Rheumatoid arthritis ( 24390342 30423114 ) Ulcerative colitis ( 21297633 28067908 ) Waist-hip ratio ( 28552196 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: AP1S1 CRY2 IDH3B IMP3 MUTYH SLC7A10	1 novel interactors: TNFRSF9
Interacting Genes		7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3	6 interacting genes: ATXN2 IDH3A IDH3G MAPK6 PRMT1 RAB35
Entrez ID		3604	3420
HPRD ID		03767	05163
Ensembl ID		ENSG00000049249	ENSG00000101365
Uniprot IDs		Q07011	A0A087WZN1 A0A087X2E5 O43837
PDB IDs		6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3	6KDE 6KDF 6KDY 6KE3 7CE3 8GRB 8GRD 8GRU 8GS5
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex	Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor GATOR1 Complex Binding Septin Cytoskeleton Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Cellular Response To Methionine Magnesium Ion Binding