TNFRSF9 and SERP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFRSF9	SERP1
Description		TNF receptor superfamily member 9	stress associated endoplasmic reticulum protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion
Pathways		TNFs bind their physiological receptors	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Urelumab
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Psoriasis ( 23143594 25903422) Rheumatoid arthritis ( 24390342 30423114) Ulcerative colitis ( 21297633 28067908) Waist-hip ratio ( 28552196)	Academic attainment (English) ( 33594131)
Interacting Genes		7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3	56 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9
Entrez ID		3604	27230
HPRD ID		03767	18037
Ensembl ID		ENSG00000049249	ENSG00000120742
Uniprot IDs		Q07011	Q9Y6X1
PDB IDs		6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex	Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity
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