TNFRSF9 and AP1S1

Data Source: HiPPIP (Novel)

		TNFRSF9	AP1S1
Name		TNF receptor superfamily member 9	adaptor related protein complex 1 subunit sigma 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation	Intracellular Protein Transport Receptor-mediated Endocytosis Response To Virus Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		TNFs bind their physiological receptors	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		Urelumab	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Celiac disease ( 20190752 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 28067908 ) Psoriasis ( 23143594 25903422 ) Rheumatoid arthritis ( 24390342 30423114 ) Ulcerative colitis ( 21297633 28067908 ) Waist-hip ratio ( 28552196 )	Adult body size ( 32376654 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 )
Novel Interactors		6 novel interactors: AP1S1 CRY2 IDH3B IMP3 MUTYH SLC7A10	1 novel interactors: TNFRSF9
Interacting Genes		7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3	6 interacting genes: AP1G1 AP1G2 AP1M2 AP2A2 PICK1 RHOU
Entrez ID		3604	1174
HPRD ID		03767	04635
Ensembl ID		ENSG00000049249	ENSG00000106367
Uniprot IDs		Q07011	P61966
PDB IDs		6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3	4P6Z
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex	Clathrin Adaptor Activity AP-1 Adaptor Complex Membrane Coat Intracellular Protein Transport Basolateral Protein Secretion Clathrin Adaptor Complex Trans-Golgi Network Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Intracellular Vesicle Golgi To Vacuole Transport Cytoplasmic Vesicle Membrane Establishment Of Protein Localization Golgi Apparatus Golgi Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Presynaptic Endocytosis Cytoplasmic Vesicle Intracellular Protein Localization Clathrin-coated Pit Endocytic Vesicle Membrane Clathrin-coated Vesicle Endocytosis Vesicle-mediated Transport In Synapse Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Budding From Endosome Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Import Into Cell Membrane Membrane Curvature Sensor Activity Vacuolar Transport Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Actin Nucleation Positive Regulation Of Focal Adhesion Disassembly Protein Domain Specific Binding Presynapse Endosome To Melanosome Transport AP-2 Adaptor Complex Golgi To Lysosome Transport Neuronal Ion Channel Clustering Dendritic Spine Maintenance Synapse