TMEM230 and HTR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TMEM230	HTR4
Description		transmembrane protein 230	5-hydroxytryptamine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Synaptic Vesicle Endomembrane System Membrane Axon Cytoplasmic Vesicle Synapse Recycling Endosome	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Synaptic Vesicle Transport Axonal Transport	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways			Serotonin receptors G alpha (s) signalling events
Drugs			Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS			Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		14 interacting genes: AQP2 ARL4D CREB3 ERBB2 ERBB3 ERBB4 HTR4 LMNA MTNR1A MTNR1B RPL28 SGTA TMEM9 VKORC1	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		29058	3360
HPRD ID		12762	09074
Ensembl ID		ENSG00000089063	ENSG00000164270
Uniprot IDs		A0A087WTT2 Q96A57	A0A2D3FAF9 Q13639
PDB IDs			5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Melatonin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Complex Basal Plasma Membrane Protein-containing Complex Localization ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basolateral Plasma Membrane ERBB Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Membrane Regulation Of Body Fluid Levels Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Tyrosine Kinase Activity Peripheral Nervous System Development Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Biological Quality Growth Factor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Localization Within Membrane Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Animal Organ Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Large Intestinal Transit Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Protein Localization To Synapse Heart Development Glial Cell Development Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cardiac Muscle Tissue Development	Membrane Endoplasmic Reticulum Membrane
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