CCNDBP1 and SPG7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CCNDBP1	SPG7
Description		cyclin D1 binding protein 1	SPG7 matrix AAA peptidase subunit, paraplegin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Membrane Axon Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process		Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Mitochondrial Membrane Permeability Regulation Of Calcium Import Into The Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1 Mitochondrial protein degradation
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS			Appendicular lean mass ( 33097823) Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		114 interacting genes: ADGRA2 AMPD2 AQP1 ARHGAP22 ATP4B C22orf23 CCDC146 CCDC187 CCND1 CDK18 CDKN2A CFAP65 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM161A FAM74A4 FH FZD10 GAS2L2 GLIDR GRAP2 GSTK1 HBZ HDAC4 HMGB1 HSPB1 HYCC1 ILF2 IMP3 IRGC LIN37 LNX1 MAP2K2 MOS MRPL15 MRPS9 MTDH NAIF1 NANOS2 NEURL3 NOL7 NSMF NUDCD3 PAXIP1 PEX39 PIAS2 PIMREG PLEKHA7 PMP2 POLDIP3 POLL PRPF31 PSMB10 PTF1A RARA RARB RBP5 RPL28 RPL39L RPL7L1 RPS28 SASH1 SHFL SIRT6 SLC16A13 SPG7 STK25 SYF2 TCEAL1 TEAD4 TFPT THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS WNT11 ZBTB24 ZGPAT ZNF124 ZNF136 ZNF155 ZNF169 ZNF20 ZNF223 ZNF230 ZNF334 ZNF394 ZNF417 ZNF439 ZNF440 ZNF480 ZNF490 ZNF552 ZNF555 ZNF557 ZNF564 ZNF578 ZNF581 ZNF627 ZNF670 ZNF696 ZNF697 ZNF707 ZNF785 ZNF786 ZNF835 ZNF837 ZNRF2P1 ZSCAN26	29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		23582	6687
HPRD ID		06156	04149
Ensembl ID		ENSG00000166946	ENSG00000197912
Uniprot IDs		B4DHB5 O95273	A0A2R8Y3M4 A0A2R8Y632 A0A2R8YFJ7 Q9UQ90
PDB IDs		3AY5	2QZ4
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Heterocyclic Compound Binding Regulation Of Metabolic Process SUMO Transferase Activity	Intermediate Filament Keratin Filament
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