CLDN22 and CLEC4C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN22	CLEC4C
Description		claudin 22	C-type lectin domain family 4 member C
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Adaptive Immune Response Immune System Process Innate Immune Response Antifungal Innate Immune Response
Pathways		Tight junction interactions	Dectin-2 family Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576)
Interacting Genes		7 interacting genes: CLEC4C CXCR2 LHFPL5 OPRM1 SPG21 TMBIM6 TREX1	3 interacting genes: CLDN22 KTN1 MAL
Entrez ID		53842	170482
HPRD ID		13068	09453
Ensembl ID		ENSG00000177300	ENSG00000198178
Uniprot IDs		Q8N7P3	Q8WTT0
PDB IDs			3WBP 3WBQ 3WBR 4ZES 4ZET
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cytosolic Calcium Ion Concentration Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Immunoglobulin Production Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Interleukin-8 Receptor Activity Secretory Granule Membrane Interleukin-8-mediated Signaling Pathway Endoribonuclease Inhibitor Activity Cellular Response To Type I Interferon DNA Exonuclease Activity Retrotransposition Transposition Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Interleukin-8 Binding Myeloid Leukocyte Activation Cellular Response To Morphine DNA Synthesis Involved In UV-damage Excision Repair Mast Cell Granule Membrane Regulation Of NMDA Receptor Activity System Process T Cell Antigen Processing And Presentation Negative Regulation Of Calcium Ion Transport Into Cytosol G Protein-coupled Opioid Receptor Activity Calcium Ion Transmembrane Transport Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response MutSalpha Complex Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity MutLalpha Complex Binding C-X-C Chemokine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Immune System Process Behavioral Response To Ethanol Calcium Ion Transport G Protein-coupled Opioid Receptor Signaling Pathway Nervous System Process IRE1-mediated Unfolded Protein Response 3'-5'-DNA Exonuclease Activity CD4 Receptor Binding Stereocilium Bundle Monoatomic Ion Transport Negative Regulation Of Immunoglobulin Production Cellular Response To Hydroxyurea	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Localization To Paranode Region Of Axon Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Membrane Raft Polarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Peptidase Activator Activity Involved In Apoptotic Process Apical Protein Localization Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Membrane Raft Organization Plasma Membrane Raft Kinesin Binding Bicellular Tight Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tight Junction Assembly Tight Junction Organization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Insertion Into Membrane
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