WFDC3 and GET3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WFDC3	GET3
Description		WAP four-disulfide core domain 3	guided entry of tail-anchored proteins factor 3, ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding
	Biological Process	Antibacterial Humoral Response Innate Immune Response	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS
Interacting Genes		2 interacting genes: GET3 LCE1F	38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		140686	439
HPRD ID		15676	03555
Ensembl ID		ENSG00000124116	ENSG00000198356
Uniprot IDs		Q8IUB2	O43681
PDB IDs			6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		GET Complex Membrane Insertase Activity Protein Insertion Into ER Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Tail-anchored Membrane Protein Insertion Into ER Membrane Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Protein Insertion Into Membrane Keratinization Antigen Processing And Presentation	Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity
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