JCHAIN and CD79A

Number of citations of the paper that reports this interaction (PubMedID 1292512)
0

Data Source:
HPRD (in vivo)

		JCHAIN	CD79A
Description		joining chain of multimeric IgA and IgM	CD79a molecule
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Membrane Raft IgM B Cell Receptor Complex
	Molecular Function	Single-stranded DNA Binding Antigen Binding IgA Binding Protein-macromolecule Adaptor Activity Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Glomerular Filtration Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Scavenging of heme from plasma	CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: CD79A IGHM	192 interacting genes: ADGRE2 ADIPOQ AGTRAP ALG10 ALG10B ALG3 APOD AQP1 AQP3 ARLN ATP6V0C BCL2L2 BET1 BLK BLNK BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CATSPERH CCDC167 CD19 CD5 CD79B CD81 CDIPT CLDN1 CLN6 CMTM5 CMTM7 CNIH1 CNIH3 COL4A5 CTSA CTXN3 CYB561 CYB561A3 CYB561D2 CYB5B DEFB127 DOLK EDDM3B EMC6 EMP1 EMP3 FA2H FAM241B FANCA FATE1 FAXDC2 FCAR FDFT1 FFAR3 FKBP8 FUNDC2 FXYD3 FYN GALNT15 GIMAP1 GJB1 GPR42 HACD4 HCLS1 HMOX1 HMOX2 HTATIP2 IER3 IGHM INSIG2 ITGAM JAGN1 JCHAIN KCNS2 LAMB1 LCK LEPROTL1 LHFPL5 LNPEP LPAR3 LTC4S LYN MALL MARCHF2 MFF MFSD12 MFSD6 MGLL MMD2 MOSPD3 MS4A13 MYADM MYADML2 NAT8 NEU1 NINJ2 NIPAL3 NKG7 ORMDL1 ORMDL2 OTOP2 PEX16 PGAP2 PIGR PKMYT1 PLP2 PLPP6 PLPPR2 PNLIPRP1 PRAF2 PTCH1 PTPN6 REEP6 RHO RTP2 SACM1L SEC22B SERP1 SFTPC SLC13A4 SLC13A5 SLC16A12 SLC16A13 SLC30A2 SLC30A3 SLC35B1 SLC35B4 SLC38A1 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC46A3 SLC61A1 SLC66A2 SLC6A12 SLC7A1 SMCO4 SMIM3 STRIT1 STX12 STX3 STX8 SYK SYNJ2BP TECR THBD TM4SF19 TM4SF4 TMBIM6 TMEM107 TMEM11 TMEM128 TMEM140 TMEM147 TMEM14B TMEM176A TMEM187 TMEM19 TMEM218 TMEM222 TMEM229B TMEM239 TMEM243 TMEM254 TMEM42 TMEM86A TMEM86B TMEM97 TMPPE TNFRSF10C TRAM1L1 TRARG1 TSNARE1 TSPAN2 TSPO2 UBE2J1 UBIAD1 UNC93B1 UPK1B VAMP3 VAMP4 VAPA VAPB VTI1B WFDC2 WFS1 YIF1A YIPF4 YIPF6 ZDHHC15 ZDHHC22
Entrez ID		3512	973
HPRD ID		00991	00203
Ensembl ID		ENSG00000132465	ENSG00000105369
Uniprot IDs		P01591	P11912
PDB IDs		6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7Y09 7Y0H 7Y0J 7YG2 7YSG 7YTC 7YTD 8ADY 8ADZ 8AE0 8AE2 8AE3 8BPE 8BPF 8GZN 8R83 8R84 8SKU 8SKV 8WYR 8WYS 9ARV	1CV9 7WSO 7WSP 7XQ8 7XT6
Enriched GO Terms of Interacting Partners?		IgM B Cell Receptor Complex B Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Adaptive Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Immune Response-activating Signaling Pathway B Cell Receptor Complex IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune Response Immunoglobulin Receptor Binding Peptidoglycan Binding Immunoglobulin Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Phosphatidylcholine Binding Antigen Binding Immune Response B Cell Proliferation Multivesicular Body Antibacterial Humoral Response Regulation Of Immune System Process Defense Response To Gram-negative Bacterium B Cell Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Immune System Process Single-stranded DNA Binding Blood Microparticle Leukocyte Proliferation Antimicrobial Humoral Response	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding B Cell Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Golgi Membrane SNAP Receptor Activity SNARE Complex Antigen Receptor-mediated Signaling Pathway Cellular Localization Membrane Docking Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Fusion Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Organelle Localization By Membrane Tethering Vesicle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Localization Within Membrane Protein Localization To Membrane T Cell Costimulation Chemical Homeostasis Membrane Organization Cholesterol Binding Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Monoatomic Cation Transmembrane Transporter Activity Intracellular Chemical Homeostasis Fc Receptor Signaling Pathway Metal Ion Transport Vesicle Fusion With Golgi Apparatus Vesicle-mediated Transport Endomembrane System Immune Response-activating Signaling Pathway Vesicle Docking Inorganic Cation Transmembrane Transport Membrane Lipid Metabolic Process Vacuolar Transmembrane Transport Phospholipase Binding Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Immune System Process Establishment Of Localization In Cell Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transport
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