JCHAIN

Description		joining chain of multimeric IgA and IgM
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Antigen Binding IgA Binding Protein-macromolecule Adaptor Activity Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding
	Biological Process	Adaptive Immune Response Glomerular Filtration Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly
Pathways		Cell surface interactions at the vascular wall Scavenging of heme from plasma
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS
Interacting Genes		2 interacting genes: CD79A IGHM
Entrez ID		3512
HPRD ID		00991
Ensembl ID		ENSG00000132465
Uniprot IDs		P01591
PDB IDs		6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7Y09 7Y0H 7Y0J 7YG2 7YSG 7YTC 7YTD 8ADY 8ADZ 8AE0 8AE2 8AE3 8BPE 8BPF 8GZN 8R83 8R84 8SKU 8SKV 8WYR 8WYS 9ARV
Enriched GO Terms of Interacting Partners?		IgM B Cell Receptor Complex B Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Adaptive Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Immune Response-activating Signaling Pathway B Cell Receptor Complex IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune Response Immunoglobulin Receptor Binding Peptidoglycan Binding Immunoglobulin Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Phosphatidylcholine Binding Antigen Binding Immune Response B Cell Proliferation Multivesicular Body Antibacterial Humoral Response Regulation Of Immune System Process Defense Response To Gram-negative Bacterium B Cell Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Immune System Process Single-stranded DNA Binding Blood Microparticle Leukocyte Proliferation Antimicrobial Humoral Response
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