NIPAL4 and ACKR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NIPAL4	ACKR2
Description		NIPA like domain containing 4	atypical chemokine receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome
	Molecular Function	Protein Binding Magnesium Ion Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity
	Biological Process	Monoatomic Ion Transport Magnesium Ion Transport Magnesium Ion Transmembrane Transport	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Miscellaneous transport and binding events	Chemokine receptors bind chemokines
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Asthma ( 31959851)	Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)
Interacting Genes		15 interacting genes: ACKR2 CLDN7 CMTM2 COMT FFAR2 GJB1 GPR152 HHLA2 IL10RA LHFPL5 RNF185 RNF19B SSMEM1 TM4SF18 TRHR	25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B
Entrez ID		348938	1238
HPRD ID		19424	09095
Ensembl ID		ENSG00000172548	ENSG00000144648
Uniprot IDs		Q0D2K0	O00590
PDB IDs			8GO9 8J8V 8J8Z
Enriched GO Terms of Interacting Partners?		Membrane	Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis
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