Description |
apolipoprotein E |
HtrA serine peptidase 1 |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Advanced age-related macular degeneration ( 26691988)
- Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807)
- Age-related macular degeneration (choroidal neovascularisation) ( 22705344)
- Age-related macular degeneration (CNV vs. GA) ( 22705344)
- Age-related macular degeneration (extreme sampling) ( 23577725)
- Age-related macular degeneration (geographic atrophy) ( 22705344)
- Age-related macular degeneration (MTAG) ( 32277175)
- Age-related macular degeneration (wet) ( 17053108)
- Coronary artery disease ( 33020668 29212778)
- Disease progression in age-related macular degeneration ( 29346644)
- Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644)
- Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644)
- Diverticular disease ( 30177863)
- Early age-related macular degeneration ( 32843070)
- Exudative age-related macular degeneration ( 25629512)
- Laterality in neovascular age-related macular degeneration ( 28775256)
- Lung function (FEV1/FVC) ( 30804560 30061609)
- Migraine ( 27322543)
- Myocardial infarction ( 33532862)
- Neovascular age-related macular degeneration ( 28703135)
- Refractive error ( 32231278)
- Systolic blood pressure ( 30578418 30224653)
- White matter hyperintensity volume ( 33293549)
- White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
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Interacting Genes |
61 interacting genes:
A2M
ACE2
AKT1
ALB
ANKH
APP
ARFGAP1
CDC37
CNTF
CSNK2A1
CTSB
CYP2C18
CYP2C8
ECSIT
ELAVL1
EPN2
FARSA
FBXL12
FOXG1
FXYD7
GCDH
HSP90AA1
HTRA1
IFIT3
IFIT5
IQSEC1
LCAT
LDLR
LINC02582
LONP1
LOXL4
LRP1
LRP2
LRP8
MAP2
MAPT
MAST1
MID1IP1
NEFM
NOS3
PCMT1
PDCD4
PLEKHA6
PLTP
PRAM1
PRDX2
PRNP
PSEN1
RHEB
RNF32
RPL4
S100B
SCARB1
SNCA
SORL1
ST13
TIMM29
TREM2
TYRO3
VLDLR
ZNF558
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22 interacting genes:
APOE
BMP4
CAST
CDYL
COL1A1
COL2A1
COL3A1
COX5A
CSNK2B
FAM107A
FCHSD2
GDF5
GOLGA2
IMPDH1
LRP10
LTBP1
MAPT
NOS3
PARD6B
RPS6KA1
TENT5A
XIAP
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Entrez ID |
348 |
5654 |
HPRD ID |
00135 |
03725 |
Ensembl ID |
ENSG00000130203
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ENSG00000166033
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Uniprot IDs |
A0A0S2Z3D5
P02649
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Q92743
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PDB IDs |
1B68
1BZ4
1EA8
1GS9
1H7I
1LE2
1LE4
1LPE
1NFN
1NFO
1OEF
1OEG
1OR2
1OR3
2KC3
2KNY
2L7B
6IWB
6NCN
6NCO
7FCR
7FCS
7UVJ
8AX8
8AX9
8CDY
8CE0
8GRX
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2JOA
2YTW
3NUM
3NWU
3NZI
3TJN
3TJO
3TJQ
6Z0E
6Z0X
6Z0Y
7SJN
7SJO
7SJP
8SDM
8SDP
8SE7
8SE8
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Enriched GO Terms of Interacting Partners? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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