APOE and HTRA1

  • Number of citations of the paper that reports this interaction (PubMedID 21163940)
  • 58
  • Data Source:
  • BioGRID (two hybrid)

APOE

HTRA1

Description apolipoprotein E HtrA serine peptidase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Advanced age-related macular degeneration ( 26691988)
  • Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807)
  • Age-related macular degeneration (choroidal neovascularisation) ( 22705344)
  • Age-related macular degeneration (CNV vs. GA) ( 22705344)
  • Age-related macular degeneration (extreme sampling) ( 23577725)
  • Age-related macular degeneration (geographic atrophy) ( 22705344)
  • Age-related macular degeneration (MTAG) ( 32277175)
  • Age-related macular degeneration (wet) ( 17053108)
  • Coronary artery disease ( 33020668 29212778)
  • Disease progression in age-related macular degeneration ( 29346644)
  • Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644)
  • Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644)
  • Diverticular disease ( 30177863)
  • Early age-related macular degeneration ( 32843070)
  • Exudative age-related macular degeneration ( 25629512)
  • Laterality in neovascular age-related macular degeneration ( 28775256)
  • Lung function (FEV1/FVC) ( 30804560 30061609)
  • Migraine ( 27322543)
  • Myocardial infarction ( 33532862)
  • Neovascular age-related macular degeneration ( 28703135)
  • Refractive error ( 32231278)
  • Systolic blood pressure ( 30578418 30224653)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes 61 interacting genes: A2M ACE2 AKT1 ALB ANKH APP ARFGAP1 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HSP90AA1 HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LINC02582 LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 S100B SCARB1 SNCA SORL1 ST13 TIMM29 TREM2 TYRO3 VLDLR ZNF558 22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID 348 5654
HPRD ID 00135 03725
Ensembl ID ENSG00000130203 ENSG00000166033
Uniprot IDs A0A0S2Z3D5 P02649 Q92743
PDB IDs 1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B 6IWB 6NCN 6NCO 7FCR 7FCS 7UVJ 8AX8 8AX9 8CDY 8CE0 8GRX 2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8
Enriched GO Terms of Interacting Partners?
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