APOE and TREM2

Number of citations of the paper that reports this interaction (PubMedID 27477018)
0

Data Source:
BioGRID (pull down)

		APOE	TREM2
Description		apolipoprotein E	triggering receptor expressed on myeloid cells 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Melanosome Chylomicron Neuronal Cell Body Synaptic Cleft Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Multivesicular Body, Internal Vesicle Glutamatergic Synapse Extracellular Vesicle Lipoprotein Particle	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Plasma Membrane Raft
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Structural Molecule Activity Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Antioxidant Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Chelating Activity Protein Dimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding Beta-catenin Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Semaphorin Receptor Activity Kinase Activator Activity Low-density Lipoprotein Particle Binding Semaphorin Receptor Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Carbohydrate Derivative Binding Sulfatide Binding Protein Tyrosine Kinase Binding
	Biological Process	Response To Reactive Oxygen Species Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Catabolic Process Lipid Transport Intracellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Response To Oxidative Stress Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Synaptic Transmission, Cholinergic Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Lipid Transport Involved In Lipid Storage Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Long-chain Fatty Acid Transport Protein Import Virion Assembly Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Neuron Projection Development Melanosome Organization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Locomotory Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Regulation Of Apoptotic Process Amyloid Precursor Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Host-mediated Activation Of Viral Process Regulation Of Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Smooth Muscle Cell Proliferation Artery Morphogenesis Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Lipid Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Maintenance Of Location In Cell Lipid Homeostasis Fatty Acid Homeostasis Acylglycerol Homeostasis Artery Development Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Development Regulation Of Proteasomal Protein Catabolic Process Response To Caloric Restriction Triglyceride Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipoprotein Particle Stimulus Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Clearance Circulatory System Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Cellular Oxidant Detoxification Positive Regulation Of Lipoprotein Transport Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood-brain Barrier Positive Regulation Of Lipid Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Amyloid Fibril Formation Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Regulation Of Behavioral Fear Response	Microglial Cell Activation Microglial Cell Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Triglyceride Storage Positive Regulation Of High-density Lipoprotein Particle Clearance Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Potassium Ion Transport Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Cell Development Response To Axon Injury Positive Regulation Of Protein Secretion Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Regulation Of Biological Quality Pyroptotic Inflammatory Response Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Hypoxia Semaphorin-plexin Signaling Pathway Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Dendritic Spine Maintenance Amyloid-beta Clearance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Alzheimer's disease (AD) Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Lipoprotein glomerulopathy	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		Abdominal aortic aneurysm ( 32981348) Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Age-related macular degeneration ( 23326517 23455636) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer disease and age of onset ( 26830138) Alzheimer's disease ( 17975299 17998437 18823527 19125160 19734902 19734903 20061627 20460622 21627779 22245343 22832961 24755620 24770881 30636644 31473137 33074286) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137 26339675 28714976 30617256) Alzheimer's disease (onset at age over 80) ( 30979435) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 21123754 23419831 23562540) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Alzheimer's disease progression score ( 29860282) Alzheimer’s disease (clinical subgroup AD+) ( 31473137) Alzheimer’s disease (clinical subgroup AD++) ( 31473137) Alzheimer’s disease (clinical subgroup AD+++) ( 31473137) Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD+) ( 31473137) Apolipoprotein A1 levels ( 32203549) Apolipoprotein Levels ( 23031429) Aspartate aminotransferase levels ( 33547301) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 18439548 18439552 19567438 23844046) C-reactive protein levels ( 29403010 29878111 30388399 33339817) Cardiovascular risk factors ( 20838585) Carotid intima media thickness ( 30510157) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in APOEe4 carrier Alzheimer’s disease ( 34020725) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebral microbleeds ( 32913026) Cerebral microbleeds (lobar) ( 32913026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 28641921 29274321 30319691) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 30319691) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911 20686565 24097068 25961943 28270201) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870) Cognitive decline (age-related) ( 24468470 28078323) Cognitive impairment test score ( 30319691) Coronary artery disease ( 26343387 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Dementia with Lewy bodies ( 29263008 31065058) Family history of Alzheimer's disease ( 30617256) Fasting triglyceride levels ( 32603185) Fish- and plant-related diet ( 32066663) Free cholesterol levels in large LDL ( 29084231) Fruit consumption ( 32066663) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 19060911 20686565 21909109 24097068 25961943 28270201 30275531) HDL cholesterol levels ( 26690388 28334899 32203549) HDL cholesterol levels in HIV infection ( 33109212) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Hippocampal atrophy ( 22745009) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 27863252) Lamb consumption ( 32066663) Late-onset Alzheimer's disease ( 29360470) LDL cholesterol ( 18193043 18193044 18802019 19060906 19060911 20686565 20864672 23067351 23726366 24097068 24507774 25961943 26160806) LDL cholesterol levels ( 17463246 26763881 28334899 28371326 31087446 32759990) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lewy body disease ( 25188341) Lipid metabolism phenotypes ( 22286219) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 24023260 30576415) Lipoprotein (a) levels ( 28512139 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Lobar intracerebral hemorrhage ( 31430377) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511 31484785) Longevity (100 years and older) ( 33948810) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Low density lipoprotein cholesterol levels ( 28548082 29403010 30718733 33339817) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Moderate to vigorous physical activity levels ( 29899525) Mortality ( 27029810) Myocardial infarction ( 33532862) Neuritic plaque ( 31497858) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 31497858) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Nonalcoholic fatty liver disease ( 34841290) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965 31484785) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease progression (cognitive) ( 33111402) Parkinson's disease progression (composite) ( 33111402) Percent liver fat ( 34128465) Plasma amyloid beta peptide concentration (ABx-40/ABx-42 ratio) ( 34002480) Plasma amyloid beta peptide concentrations (ABx-42) ( 34002480) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Postprandial triglyceride levels ( 32603185) Psychosis and Alzheimer's disease ( 22005930) Pulse pressure ( 30224653 30578418) Quantitative traits ( 19197348) Red cell distribution width ( 27863252 28957414 32888494) Refractive error ( 32231278) Relative sugar intake ( 32393786) Response to statins (LDL cholesterol change) ( 22331829 25350695) Resting heart rate ( 27798624) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum C-reactive protein concentration ( 32928877) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total cholesterol levels ( 29084231 33134509) Serum type 1 collagen metabolite levels ( 33134509) Systolic blood pressure ( 30578418) Total cholesterol levels ( 26690388 28334899 28548082 29403010 30718733 31087446 32759990 33339817) Total cholesterol levels in LDL ( 29084231) Triglyceride levels ( 28334899 29403010 30718733 33339817) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 19060911 20686565 24507774 25961943 26582766) Type 2 diabetes ( 27189021 28869590 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Vigorous physical activity ( 29899525) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)
Interacting Genes		61 interacting genes: A2M ACE2 AKT1 ALB ANKH APP ARFGAP1 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HSP90AA1 HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LINC02582 LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 S100B SCARB1 SNCA SORL1 ST13 TIMM29 TREM2 TYRO3 VLDLR ZNF558	10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B
Entrez ID		348	54209
HPRD ID		00135	05473
Ensembl ID		ENSG00000130203	ENSG00000095970
Uniprot IDs		A0A0S2Z3D5 P02649	Q5TCX1 Q9NZC2
PDB IDs		1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B 6IWB 6NCN 6NCO 7FCR 7FCS 7UVJ 8AX8 8AX9 8CDY 8CE0 8GRX	5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I 8T51 8T59
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Astrocyte Activation Low-density Lipoprotein Particle Binding Positive Regulation Of Protein Catabolic Process High-density Lipoprotein Particle Endocytosis Memory Positive Regulation Of Catabolic Process Amyloid-beta Metabolic Process Regulation Of Multicellular Organismal Process Amyloid-beta Binding High-density Lipoprotein Particle Binding Regulation Of Defense Response Import Into Cell Regulation Of Nervous System Development Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Astrocyte Activation Involved In Immune Response Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Apoptotic Process Receptor-mediated Endocytosis Retinoid Metabolic Process Main Axon Apolipoprotein A-I Binding Positive Regulation Of Lysosomal Protein Catabolic Process Very-low-density Lipoprotein Particle Binding Diterpenoid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Amyloid Fibril Formation Regulation Of Immune Response Negative Regulation Of Signaling Very-low-density Lipoprotein Particle Receptor Complex Neuronal Cell Body Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Neurogenesis Cellular Response To Amyloid-beta Terpenoid Metabolic Process Regulation Of Phospholipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Phosphorus Metabolic Process Molecular Function Activator Activity Cargo Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Protein Metabolic Process Protein-folding Chaperone Binding Isoprenoid Metabolic Process	Chylomicron Cellular Response To Amyloid-beta Response To Amyloid-beta Reverse Cholesterol Transport Cholesterol Transport Very-low-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Sterol Transport Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling High-density Lipoprotein Particle Clearance Receptor Ligand Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Endocytosis High-density Lipoprotein Particle Assembly Organic Hydroxy Compound Transport Phospholipid Efflux Low-density Lipoprotein Particle Low-density Lipoprotein Particle Remodeling Extracellular Space Endocytic Vesicle Lumen Sterol Homeostasis High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis High-density Lipoprotein Particle Chylomicron Remnant Positive Regulation Of Neurofibrillary Tangle Assembly Low-density Lipoprotein Particle Receptor Binding Cholesterol Metabolic Process Lipid Transport Regulation Of Endocytosis Phospholipid Binding Blood Microparticle Sterol Metabolic Process Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Lipid Homeostasis Extracellular Region Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding
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