APOE and VLDLR

Number of citations of the paper that reports this interaction (PMID 12167620)
81

Data Source:
HPRD (in vivo)

		APOE	VLDLR
Gene Name		apolipoprotein E	very low density lipoprotein receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Microtubule Plasma Membrane Membrane Dendrite Extracellular Matrix Extrinsic Component Of External Side Of Plasma Membrane Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Plasma Membrane Coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Beta-amyloid Binding Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Cholesterol Binding Antioxidant Activity Cholesterol Transporter Activity Identical Protein Binding Protein Homodimerization Activity Hydroxyapatite Binding Metal Chelating Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Glycoprotein Transporter Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Response To Reactive Oxygen Species Retinoid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Triglyceride Metabolic Process Cholesterol Catabolic Process Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Synaptic Transmission, Cholinergic Aging Phototransduction, Visible Light Cholesterol Metabolic Process Regulation Of Gene Expression Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Peripheral Nervous System Axon Regeneration Long-chain Fatty Acid Transport Protein Import Triglyceride Catabolic Process CGMP-mediated Signaling Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Positive Regulation Of CGMP Biosynthetic Process Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Response To Retinoic Acid Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Insulin Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Small Molecule Metabolic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Axon Extension Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Artery Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Lipid Biosynthetic Process Maintenance Of Location In Cell Fatty Acid Homeostasis Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Development Cellular Response To Interleukin-1 Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Negative Regulation Of Cholesterol Efflux Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Beta-amyloid Formation Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Phospholipid Efflux Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Dendrite Development
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Visual phototransduction Scavenging by Class A Receptors Retinoid metabolism and transport
Drugs		Human Serum Albumin Serum albumin iodonated
Diseases
GWAS		Age-related macular degeneration ( 23326517 23455636) Alzheimer's disease ( 17975299 22832961 20460622 17998437 18823527 19734902 19734903 21627779 19125160 20061627 22245343) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Apolipoprotein Levels ( 23031429) Brain imaging ( 20100581) C-reactive protein ( 19567438 18439548 18439552) Cardiovascular disease risk factors ( 20838585) Cholesterol, total ( 19060911 20686565) Cognitive decline ( 22054870) HDL cholesterol ( 21909109 19060911 20686565) Hippocampal atrophy ( 22745009) LDL cholesterol ( 23726366 18802019 18193043 18193044 20864672 19060906 19060911 23067351 20686565) Lipid metabolism phenotypes ( 22286219) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Longevity ( 21418511) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Quantitative traits ( 19197348) Response to statin therapy (LDL-C) ( 22331829) Triglycerides ( 19060911 20686565)	Alzheimer's disease (age of onset) ( 22005931) Gambling ( 22780124) Vascular endothelial growth factor levels ( 21757650)
Protein-Protein Interactions		54 interactors: A2M ACTG1 ALB ANKH APP ARFGAP1 C19orf52 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 SCARB1 ST13 TYRO3 VLDLR ZNF558	9 interactors: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17
Entrez ID		348	7436
HPRD ID		00135	01895
Ensembl ID		ENSG00000130203	ENSG00000147852
Uniprot IDs		P02649	P98155 Q5VVF5
PDB IDs		1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B	1V9U 3DPR
Enriched GO Terms of Interacting Partners?		Endocytosis Steroid Metabolic Process Vesicle-mediated Transport Cholesterol Metabolic Process Lipid Metabolic Process Sterol Metabolic Process Receptor-mediated Endocytosis Developmental Process Response To External Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Alcohol Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Programmed Cell Death Anatomical Structure Morphogenesis Cellular Response To Stimulus Multicellular Organismal Development Phototransduction, Visible Light Blood Coagulation Retinoid Metabolic Process Negative Regulation Of Cell Death Hemostasis Regulation Of Cellular Protein Metabolic Process Wound Healing Negative Regulation Of Neuron Apoptotic Process Lipoprotein Metabolic Process System Development Diterpenoid Metabolic Process Regulation Of Phosphorus Metabolic Process Anatomical Structure Development Lipid Transport Detection Of Visible Light Nervous System Development Apoptotic Cell Clearance Transport Phototransduction Small Molecule Metabolic Process Platelet Activation Lipid Localization Generation Of Neurons Plasma Lipoprotein Particle Clearance Negative Regulation Of Neuron Death Detection Of Light Stimulus Response To Wounding Reelin-mediated Signaling Pathway	Regulation Of Beta-amyloid Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Lateral Motor Column Neuron Migration Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Cholesterol Transport Sterol Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Beta-amyloid Formation Triglyceride-rich Lipoprotein Particle Remodeling Receptor-mediated Endocytosis CGMP-mediated Signaling Cholesterol Catabolic Process Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Cell Differentiation Lipid Homeostasis Positive Regulation Of Cholesterol Storage Negative Regulation Of Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Regulation Of Beta-amyloid Formation Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Triglyceride Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Steroid Catabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Acylglycerol Catabolic Process Glial Cell Differentiation Plasma Lipoprotein Particle Remodeling Regulation Of Protein Metabolic Process Positive Regulation Of Dendritic Spine Development Lipid Metabolic Process Positive Regulation Of Lipid Storage Postsynaptic Membrane Organization Regulation Of Phosphorylation Plasma Lipoprotein Particle Clearance Cyclic-nucleotide-mediated Signaling Positive Regulation Of Protein Catabolic Process Endocytosis Cellular Localization Gliogenesis
Tagcloud ?		aa adenovirus agreement amyloid amyloids apoe3 apoe4 apoj apolipoprotein apolipoproteins appear cerebral characterize deficient define deposition deposits fibril fibrillogenesis fibrils fragment greatest heterozygous injected lacking lipoproteins promoting restored utilized	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Difference) ?		aa adenovirus agreement amyloid amyloids apoe3 apoe4 apoj apolipoprotein apolipoproteins appear cerebral characterize deficient define deposition deposits fibril fibrillogenesis fibrils fragment greatest heterozygous injected lacking lipoproteins promoting restored utilized	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Intersection) ?