ENTPD3 and GGT6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ENTPD3	GGT6
Description		ectonucleoside triphosphate diphosphohydrolase 3	gamma-glutamyltransferase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Apyrase Activity GDP Phosphatase Activity Protein Binding ATP Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity UDP Phosphatase Activity	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Nucleoside Diphosphate Catabolic Process Nucleoside Triphosphate Catabolic Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene D4 Biosynthetic Process
Pathways		Phosphate bond hydrolysis by NTPDase proteins	Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Neuroticism ( 29255261)	Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524)
Interacting Genes		16 interacting genes: ARL13B CREB3L1 ERGIC3 FAM209A FNDC9 GGT6 GPA33 IFNGR2 LEUTX LHFPL5 LMNA MUC1 PTPN5 STX2 SYNE4 TMEM106A	10 interacting genes: ADAM33 BMP10 ENTPD3 FAIM2 FAM3C GRINA NOTCH3 SEC22A TMBIM1 TNMD
Entrez ID		956	124975
HPRD ID		16014	08293
Ensembl ID		ENSG00000168032	ENSG00000167741
Uniprot IDs		O75355	B4DKN3 B4DPG6 J3KPJ0 Q6P531 Q6ZPD7
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity	Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Calcium Ion Transmembrane Transport Golgi Membrane Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Apoptotic Signaling Pathway Negative Regulation Of Fas Signaling Pathway Apyrase Activity Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Cerebellar Granular Layer Development
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