ENTPD3 and PTPN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ENTPD3	PTPN5
Description		ectonucleoside triphosphate diphosphohydrolase 3	protein tyrosine phosphatase non-receptor type 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cell Junction
	Molecular Function	Nucleotide Binding Apyrase Activity GDP Phosphatase Activity Protein Binding ATP Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity UDP Phosphatase Activity	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Nucleoside Diphosphate Catabolic Process Nucleoside Triphosphate Catabolic Process	Protein Dephosphorylation Signal Transduction
Pathways		Phosphate bond hydrolysis by NTPDase proteins	Interleukin-37 signaling
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Neuroticism ( 29255261)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ARL13B CREB3L1 ERGIC3 FAM209A FNDC9 GGT6 GPA33 IFNGR2 LEUTX LHFPL5 LMNA MUC1 PTPN5 STX2 SYNE4 TMEM106A	19 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FYN MAPK1 MAPK3 MARCHF5 MOB1A PRKN SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5
Entrez ID		956	84867
HPRD ID		16014	01472
Ensembl ID		ENSG00000168032	ENSG00000110786
Uniprot IDs		O75355	B7Z2F8 P54829 Q86TL3
PDB IDs			2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R 8SLS 8SLT 8SLU 9EEX 9EEY 9EEZ
Enriched GO Terms of Interacting Partners?		Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity	Positive Regulation Of Cellular Component Organization Positive Regulation Of Defense Response ERBB2 Signaling Pathway Interleukin-34-mediated Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Organelle Organization Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Defense Response Negative Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamate Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Inflammatory Response Immune Response-activating Signaling Pathway Bergmann Glial Cell Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Immune Response ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Protein K27-linked Ubiquitination Regulation Of Golgi Organization MAP Kinase Activity Pseudopodium Organelle Localization Layer Formation In Cerebral Cortex Response To L-glutamate Positive Regulation Of Macroautophagy Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Phospholipase Binding Positive Regulation Of Mitochondrial Fission Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Chromosome Organization Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Protein K48-linked Ubiquitination Face Development Regulation Of Telomere Maintenance
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