CCDC22 and CPNE4

Number of citations of the paper that reports this interaction (PMID 12522145)
20

Data Source:
HPRD (two hybrid, in vitro)

		CCDC22	CPNE4
Gene Name		coiled-coil domain containing 22	copine IV
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding Cullin Family Protein Binding
	Biological Process	Cellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Cytoplasmic Sequestering Of NF-kappaB Biological_process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728) Neutrophil count ( 21507922)
Protein-Protein Interactions		5 interactors: ACTG1 BLOC1S6 CPNE1 CPNE4 USHBP1	16 interactors: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O
Entrez ID		28952	131034
HPRD ID		06594	05017
Ensembl ID		ENSG00000101997	ENSG00000196353
Uniprot IDs		O60826	Q96A23
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Blood Coagulation Hemostasis Endosome To Melanosome Transport Pigment Granule Maturation Synaptic Vesicle Docking Cellular Pigment Accumulation Positive Regulation Of Pigment Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Developmental Pigmentation Wound Healing Anterograde Synaptic Vesicle Transport Response To Wounding Melanosome Organization Pigment Granule Organization Regulation Of Developmental Pigmentation Positive Regulation Of Natural Killer Cell Activation Anterograde Axon Cargo Transport Neuron Projection Development Membrane Organization Positive Regulation Of Immune System Process Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanocyte Differentiation Neuron Development Platelet Aggregation Melanosome Localization Neuroepithelial Cell Differentiation Axon Cargo Transport Sarcomere Organization Neuron Differentiation Cell Projection Organization Synaptic Vesicle Exocytosis Cellular Pigmentation Retina Homeostasis Vesicle Docking Involved In Exocytosis Developmental Pigmentation Regulation Of Immune System Process Transport Myofibril Assembly Vesicle Docking Post-Golgi Vesicle-mediated Transport Adherens Junction Organization Movement Of Cell Or Subcellular Component Membrane Docking Ephrin Receptor Signaling Pathway Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway	Cellular Component Assembly Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Protein Heterooligomerization Golgi To Plasma Membrane Transport Intracellular Transport Protein Monoubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Actin Filament Capping Organelle Transport Along Microtubule Cell Projection Organization Regulation Of Proteinase Activated Receptor Activity Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Establishment Of Localization In Cell Negative Regulation Of Tooth Mineralization Negative Regulation Of Phospholipase C Activity Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Development Negative Regulation Of Protein Complex Disassembly Transport Cell Projection Morphogenesis Vesicle-mediated Transport Minus-end-directed Organelle Transport Along Microtubule Axon Guidance Cell Part Morphogenesis Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Protein Depolymerization Regulation Of Organelle Organization Regulation Of Golgi Inheritance Protein Oligomerization Regulation Of Protein Complex Disassembly Specification Of Axis Polarity Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Cellular Localization Negative Regulation Of Protein Complex Assembly Microtubule-based Transport Regulation Of Vascular Smooth Muscle Contraction Common-partner SMAD Protein Phosphorylation Negative Regulation Of Odontogenesis
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