CCDC22 and BLOC1S6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CCDC22	BLOC1S6
Gene Name		coiled-coil domain containing 22	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleoplasm Cytoplasm Endosome Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex
	Molecular Function	Molecular_function Protein Binding Cullin Family Protein Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Cellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Cytoplasmic Sequestering Of NF-kappaB Biological_process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Synaptic Vesicle Docking Melanocyte Differentiation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation Membrane Organization Membrane Fusion
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ACTG1 BLOC1S6 CPNE1 CPNE4 USHBP1	38 interactors: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCDC53 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WDYHV1
Entrez ID		28952	26258
HPRD ID		06594	16055
Ensembl ID		ENSG00000101997	ENSG00000104164
Uniprot IDs		O60826	B3KY40 Q9UL45
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Blood Coagulation Hemostasis Endosome To Melanosome Transport Pigment Granule Maturation Synaptic Vesicle Docking Cellular Pigment Accumulation Positive Regulation Of Pigment Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Developmental Pigmentation Wound Healing Anterograde Synaptic Vesicle Transport Response To Wounding Melanosome Organization Pigment Granule Organization Regulation Of Developmental Pigmentation Positive Regulation Of Natural Killer Cell Activation Anterograde Axon Cargo Transport Neuron Projection Development Membrane Organization Positive Regulation Of Immune System Process Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanocyte Differentiation Neuron Development Platelet Aggregation Melanosome Localization Neuroepithelial Cell Differentiation Axon Cargo Transport Sarcomere Organization Neuron Differentiation Cell Projection Organization Synaptic Vesicle Exocytosis Cellular Pigmentation Retina Homeostasis Vesicle Docking Involved In Exocytosis Developmental Pigmentation Regulation Of Immune System Process Transport Myofibril Assembly Vesicle Docking Post-Golgi Vesicle-mediated Transport Adherens Junction Organization Movement Of Cell Or Subcellular Component Membrane Docking Ephrin Receptor Signaling Pathway Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway	Anterograde Synaptic Vesicle Transport Establishment Of Localization In Cell Axon Cargo Transport Melanosome Organization Pigment Granule Organization Organelle Organization Cellular Pigmentation Anterograde Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Organelle Localization Synaptic Vesicle Transport Movement Of Cell Or Subcellular Component Establishment Of Vesicle Localization Intracellular Transport Pigmentation Vesicle Organization Establishment Of Organelle Localization Vesicle Localization Membrane Organization Neuron Development Microtubule-based Process Neuron Projection Development Platelet Dense Granule Organization Microtubule-based Movement Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Vesicle-mediated Transport Protein Localization Protein Transport Establishment Of Protein Localization Cell Development Post-Golgi Vesicle-mediated Transport Generation Of Neurons Cellular Protein Localization Neurogenesis Neuron Recognition Secretory Granule Organization Transport Endomembrane System Organization Golgi Vesicle Transport Vesicle Fusion Nervous System Development Mitotic Nuclear Division Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Organelle Fusion
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