IDE and PEX5

Number of citations of the paper that reports this interaction (PMID 20178365)
7

Data Source:
BioGRID (unspecified method)

		IDE	PEX5
Gene Name		insulin-degrading enzyme	peroxisomal biogenesis factor 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Cell Surface Cytosolic Proteasome Complex	Intracellular Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein Complex
	Molecular Function	Beta-amyloid Binding Glycoprotein Binding Metalloendopeptidase Activity Receptor Binding Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Ubiquitin Binding Insulin Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Protein C-terminus Binding Enzyme Binding Small GTPase Binding Protein N-terminus Binding
	Biological Process	Proteolysis Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Homeostasis Viral Process Positive Regulation Of Protein Oligomerization Hormone Catabolic Process Negative Regulation Of Proteolysis Beta-amyloid Metabolic Process Protein Homooligomerization Protein Homotetramerization Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Insulin Metabolic Process Insulin Catabolic Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Protein Tetramerization Negative Regulation Of Protein Homotetramerization
Pathways
Drugs		Insulin Regular Insulin, porcine Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Type 2 diabetes ( 20581827)	IgG glycosylation ( 23382691)
Protein-Protein Interactions		10 interactors: APP AR IGF1 IGF2 INS NES NR3C1 PEX5 UBC UCHL5	68 interactors: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EP400NL EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PECR PEX10 PEX12 PEX13 PEX14 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP9X ZNF772
Entrez ID		3416	5830
HPRD ID		00894	02684
Ensembl ID		ENSG00000119912	ENSG00000139197
Uniprot IDs		P14735	B4DR50 B4E0T2 P50542
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSE 4GSF 4IOF	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Glucose Metabolic Process Organ Development Positive Regulation Of Mitotic Cell Cycle Regulation Of Glycogen Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction System Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Platelet Degranulation Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Multicellular Organismal Development Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Protein Oligomerization Exocrine Pancreas Development Regulation Of Multicellular Organism Growth Pancreas Development Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Glycolytic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Developmental Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	Carboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Fatty Acid Oxidation Catabolic Process Lipid Oxidation Fatty Acid Catabolic Process Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Modification Cellular Lipid Catabolic Process Lipid Catabolic Process Peroxisome Organization Oxidation-reduction Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Protein Import Into Peroxisome Matrix Cellular Metabolic Process Acyl-CoA Metabolic Process Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Bile Acid Biosynthetic Process Intracellular Protein Transmembrane Transport Cofactor Metabolic Process Protein Transmembrane Transport Lipid Biosynthetic Process Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Sulfur Compound Metabolic Process Glyoxylate Metabolic Process Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Steroid Biosynthetic Process Protein Targeting Telomere Assembly Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Steroid Metabolic Process Cellular Amino Acid Catabolic Process Long-chain Fatty Acid Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Cellular Process Dicarboxylic Acid Catabolic Process Coenzyme A Catabolic Process
Tagcloud ?		affects analogues autocrine clearly degrading des igfs inducer isoforms metalloendopeptidase neuroblastoma neuroblastomas neuroectodermal paracrine participate peptidases physiologically posttranslational programmed proteolytic rars retinoic retinoid rxr rxrs since start thermolysin tme	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Difference) ?		affects analogues autocrine clearly degrading des igfs inducer isoforms metalloendopeptidase neuroblastoma neuroblastomas neuroectodermal paracrine participate peptidases physiologically posttranslational programmed proteolytic rars retinoic retinoid rxr rxrs since start thermolysin tme	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Intersection) ?