APOC1 and APOA1

Number of citations of the paper that reports this interaction (PMID 15174051)
39

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		APOC1	APOA1
Gene Name		apolipoprotein C-I	apolipoprotein A-I
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Vesicle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Phospholipase Inhibitor Activity Fatty Acid Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity	Beta-amyloid Binding Protein Binding Phospholipid Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Secretion Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Platelet Activation Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Organ Regeneration Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Lipoprotein metabolism PPARA activates gene expression Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Chylomicron-mediated lipid transport Platelet degranulation Amyloids Response to elevated platelet cytosolic Ca2+ Scavenging by Class A Receptors Retinoid metabolism and transport Fatty acid, triacylglycerol, and ketone body metabolism Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Scavenging of heme from plasma Visual phototransduction Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 17998437) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein Levels ( 23031429) C-reactive protein ( 19567438 21300955) Carotid intima media thickness ( 21909108) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) LDL cholesterol ( 18262040 18802019 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302 20442857) Longevity ( 21740922) Quantitative traits ( 19197348) Triglycerides ( 23726366 20686565)	Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		4 interactors: APOA1 APOA2 HMP19 VKORC1	35 interactors: ABCA1 ABCA13 AKT2 APOA1BP APOA2 APOB APOC1 APOF APOL1 APP ATP5B CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR JAK3 LBP LCAT MAP7D1 MAPK6 PCMT1 PDE1A PLTP PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TTR VKORC1 ZNRD1
Entrez ID		341	335
HPRD ID		00131	02517
Ensembl ID		ENSG00000130208	ENSG00000118137
Uniprot IDs		B2R526 P02654	P02647
PDB IDs		1ALE 1ALF 1IOJ 1OPP	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 3J00 3K2S 3R2P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Phospholipid Efflux Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Phosphatidylcholine Biosynthetic Process Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Organ Regeneration Regulation Of Cytokine Production Involved In Immune Response Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phospholipid Transport Phototransduction Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Secretion Detection Of Light Stimulus Cholesterol Metabolic Process Lipid Homeostasis Isoprenoid Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cholesterol Transporter Activity Cellular Biogenic Amine Metabolic Process Sterol Metabolic Process Negative Regulation Of Immune Response	Cholesterol Metabolic Process Alcohol Metabolic Process Sterol Metabolic Process Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Reverse Cholesterol Transport High-density Lipoprotein Particle Remodeling Small Molecule Metabolic Process Lipid Metabolic Process Lipoprotein Metabolic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Transport Regulation Of Lipid Transport Protein-lipid Complex Assembly Lipid Homeostasis Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Clearance Phospholipid Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Cellular Lipid Metabolic Process Phospholipid Efflux Low-density Lipoprotein Particle Remodeling Cellular Biogenic Amine Metabolic Process Transport Amine Metabolic Process Lipopolysaccharide Transport Endocytosis Regulation Of Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Negative Regulation Of Lipid Catabolic Process Locomotion Regulation Of Phosphatidylcholine Catabolic Process Response To Lipid Chemical Homeostasis High-density Lipoprotein Particle Clearance Cell Motility Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Biosynthetic Process
Tagcloud ?		alzheimer apoe apolipoprotein augmenting autonomous carriers china chinese cognitive decline epsilon4 fulfilling genotyping guangxi h2 han impairment late longitudinal lrp mental mini onset polymorphisms rating restriction synergistically variations zhuang	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Difference) ?		alzheimer apoe apolipoprotein augmenting autonomous carriers china chinese cognitive decline epsilon4 fulfilling genotyping guangxi h2 han impairment late longitudinal lrp mental mini onset polymorphisms rating restriction synergistically variations zhuang	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Intersection) ?