APOC1 and APOA2

Number of citations of the paper that reports this interaction (PMID 6789904)
1

Data Source:
HPRD (in vitro)

		APOC1	APOA2
Gene Name		apolipoprotein C-I	apolipoprotein A-II
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Phospholipase Inhibitor Activity Fatty Acid Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity	Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Protein Folding Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Phototransduction, Visible Light Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity
Pathways			Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 17998437) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein Levels ( 23031429) C-reactive protein ( 19567438 21300955) Carotid intima media thickness ( 21909108) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) LDL cholesterol ( 18262040 18802019 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302 20442857) Longevity ( 21740922) Quantitative traits ( 19197348) Triglycerides ( 23726366 20686565)
Protein-Protein Interactions		4 interactors: APOA1 APOA2 HMP19 VKORC1	11 interactors: ABCA13 APOA1 APOA1BP APOC1 APOD APOF C4A CATSPER1 PLTP SCARB1 VKORC1
Entrez ID		341	336
HPRD ID		00131	00129
Ensembl ID		ENSG00000130208	ENSG00000158874
Uniprot IDs		B2R526 P02654	P02652
PDB IDs		1ALE 1ALF 1IOJ 1OPP	1L6L 2OU1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Phospholipid Efflux Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Phosphatidylcholine Biosynthetic Process Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Organ Regeneration Regulation Of Cytokine Production Involved In Immune Response Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phospholipid Transport Phototransduction Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Secretion Detection Of Light Stimulus Cholesterol Metabolic Process Lipid Homeostasis Isoprenoid Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cholesterol Transporter Activity Cellular Biogenic Amine Metabolic Process Sterol Metabolic Process Negative Regulation Of Immune Response	Cholesterol Efflux Lipid Transport Lipid Localization Sterol Transport Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Sterol Metabolic Process Plasma Lipoprotein Particle Clearance Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Lipid Catabolic Process High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Steroid Metabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Lipid Metabolic Process Lipid Metabolic Process Phospholipid Transport Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Alcohol Metabolic Process Small Molecule Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Regulation Of Lipid Biosynthetic Process Reverse Cholesterol Transport Negative Regulation Of Lipase Activity Lipoprotein Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Endocytosis Blood Vessel Endothelial Cell Migration Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Wound Healing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Axon Regeneration Response To Wounding Neuron Projection Regeneration Regulation Of Inflammatory Response Sperm Motility Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Phagocytosis Response To Axon Injury Negative Regulation Of Phosphatidylcholine Catabolic Process
Tagcloud ?		alzheimer apoe apolipoprotein augmenting autonomous carriers china chinese cognitive decline epsilon4 fulfilling genotyping guangxi h2 han impairment late longitudinal lrp mental mini onset polymorphisms rating restriction synergistically variations zhuang	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Difference) ?		alzheimer apoe apolipoprotein augmenting autonomous carriers china chinese cognitive decline epsilon4 fulfilling genotyping guangxi h2 han impairment late longitudinal lrp mental mini onset polymorphisms rating restriction synergistically variations zhuang	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Intersection) ?