APOC1

Gene Name		apolipoprotein C-I
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Phospholipase Inhibitor Activity Fatty Acid Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 17998437) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein Levels ( 23031429) C-reactive protein ( 19567438 21300955) Carotid intima media thickness ( 21909108) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) LDL cholesterol ( 18262040 18802019 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302 20442857) Longevity ( 21740922) Quantitative traits ( 19197348) Triglycerides ( 23726366 20686565)
Protein-protein Interactions		4 interactors: APOA1 APOA2 HMP19 VKORC1
Entrez ID		341
HPRD ID		00131
Ensembl ID		ENSG00000130208
Uniprot IDs		B2R526 P02654
PDB IDs		1ALE 1ALF 1IOJ 1OPP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Phospholipid Efflux Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Phosphatidylcholine Biosynthetic Process Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Organ Regeneration Regulation Of Cytokine Production Involved In Immune Response Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phospholipid Transport Phototransduction Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Secretion Detection Of Light Stimulus Cholesterol Metabolic Process Lipid Homeostasis Isoprenoid Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cholesterol Transporter Activity Cellular Biogenic Amine Metabolic Process Sterol Metabolic Process Negative Regulation Of Immune Response
Tagcloud ?		alzheimer apoe apolipoprotein augmenting autonomous carriers china chinese cognitive decline epsilon4 fulfilling genotyping guangxi h2 han impairment late longitudinal lrp mental mini onset polymorphisms rating restriction synergistically variations zhuang