ASB4 and HIF1AN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (in vivo)

		ASB4	HIF1AN
Description		ankyrin repeat and SOCS box containing 4	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Transcription Corepressor Activity Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity [protein]-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Metal Ion Binding NF-kappaB Binding Dioxygenase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Ankyrin Repeat Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Vasculogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Vasculogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016)	Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293)
Interacting Genes		3 interacting genes: HIF1AN ID2 UBE2D1	17 interacting genes: ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		51666	55662
HPRD ID		05770	09426
Ensembl ID		ENSG00000005981	ENSG00000166135
Uniprot IDs		Q9Y574	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S 8IHZ 8II0 8K71 8K72 8K73 9FSN 9IIF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of B Cell Differentiation Negative Regulation Of Dopaminergic Neuron Differentiation Transmembrane Transporter Binding Peyer's Patch Development Bundle Of His Development Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Enucleate Erythrocyte Differentiation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Transcription By RNA Polymerase II Endodermal Digestive Tract Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mucosa-associated Lymphoid Tissue Development Negative Regulation Of RNA Biosynthetic Process Thigmotaxis Maintenance Of Centrosome Location Potassium Channel Activator Activity Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Dendritic Branch Extrinsic Component Of Postsynaptic Density Membrane Ankyrin Repeat Binding [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Negative Regulation Of RNA Metabolic Process Potassium Channel Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Locomotor Rhythm Regulation Of Dopaminergic Neuron Differentiation Membranous Septum Morphogenesis Positive Regulation Of Astrocyte Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Vasculogenesis Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Oligodendrocyte Differentiation Response To Lithium Ion Positive Regulation Of Macrophage Differentiation Embryonic Digestive Tract Morphogenesis Mammary Gland Epithelial Cell Differentiation Cellular Response To Lithium Ion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation White Fat Cell Differentiation Positive Regulation Of Protein Polyubiquitination Regulation Of Golgi Organization Regulation Of Vasculogenesis Natural Killer Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation	Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity NF-kappaB Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Protein De-2-hydroxyisobutyrylase Activity Enzyme Binding Fungiform Papilla Formation Protein Modification Process Histone Deacetylase Binding Hair Follicle Placode Formation Histone Deacetylase Complex Transcription Corepressor Binding Cytosol DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Deacetylase Activity P53 Binding Protein Deacetylation Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Cul5-RING Ubiquitin Ligase Complex NuRD Complex Protein Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Regulation Of Apoptotic Process Protein Ubiquitination Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Circadian Rhythm Regulation Of Programmed Cell Death Heterochromatin Formation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of TOR Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?