VSX2 and ZDHHC17

Number of citations: 111 (PubMedID 24705354)
Data Source: BioGRID (two hybrid)

		VSX2	ZDHHC17
Name		visual system homeobox 2	zDHHC palmitoyltransferase 17
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Central Nervous System Neuron Differentiation Camera-type Eye Development Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Retinal Bipolar Neuron Differentiation Retina Morphogenesis In Camera-type Eye	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Diseases		Anophthalmia and microphthalmia (A/M)	None
GWAS		Cervical high-risk human papilloma virus infection ( 33225922 ) Inflammatory bowel disease ( 28008999 ) Refractive error ( 32231278 )	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009 ) Metabolite levels ( 23823483 ) Visceral fat ( 30942860 )
Interacting Genes		2 interacting genes: PAX6 ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		338917	23390
HPRD ID		08852	09697
Ensembl ID		ENSG00000119614	ENSG00000186908
Uniprot IDs		P58304	A8KA01 Q8IUH5
PDB IDs		Not available	3EU9 5W7I 5W7J
GO Terms Enriched among Interactors		Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Axonogenesis Perforant Pathway To Dendrate Granule Cell Synapse Cell Projection Morphogenesis Neuron Projection Morphogenesis Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Habenula Development Pallium Development Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Formation Of Anatomical Boundary Glial Cell Fate Specification Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Regulation Of Neurotrophin TRK Receptor Signaling Pathway HMG Box Domain Binding Co-SMAD Binding Dorsal/ventral Axis Specification Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Negative Regulation Of Neuroblast Proliferation Golgi-associated Vesicle Membrane Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation Lipoprotein Transport Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Neural Precursor Cell Proliferation Histone Acetyltransferase Binding Embryonic Eye Morphogenesis R-SMAD Binding Protein Lipidation Gland Morphogenesis	Protein Binding