KRTAP19-7 and TCAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP19-7	TCAP
Description		keratin associated protein 19-7	titin-cap
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding
	Biological Process		Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways		Keratinization	Striated Muscle Contraction
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS			Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		83 interacting genes: ANKS1A ARID5A ARMC7 ATPAF2 ATXN1L BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC24 CCNK COL8A1 CYSRT1 DAB1 DAZAP2 DTX2 EVX2 FAM168A FOXD2 FOXH1 FOXI1 GLIS2 GNE GSX1 HOMER3 HOXA1 HSF4 IRX6 KPRP KRT34 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP26-1 KRTAP3-3 KRTAP6-3 KRTAP9-2 LONRF1 MAPK1IP1L MGAT5B MKRN3 NAF1 NEU4 NOTO NOXA1 OTX1 PATZ1 PAX7 PITX1 PITX2 PLSCR3 PLSCR4 POU2AF1 POU4F2 PROP1 PRR13 PSMB1 PSMB2 RBPMS RBPMS2 RHOXF2 RNF44 ROR2 SMN1 SMN2 SPAG8 SPMIP9 TCAP TCF7L2 TEKT5 TFAP2D TLE5 TLX3 TNIP1 TOLLIP TPRX1 VAC14 VENTX VGLL3 VPS37C ZIC1	38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN
Entrez ID		337974	8557
HPRD ID		11211	05133
Ensembl ID		ENSG00000244362	ENSG00000173991
Uniprot IDs		Q3SYF9	A2TDC0 O15273
PDB IDs			1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Sequence-specific DNA Binding Keratin Filament Identical Protein Binding Nucleus Cellular Developmental Process Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Developmental Process Regionalization Myoblast Fate Commitment Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Biosynthetic Process Pattern Specification Process Somatotropin Secreting Cell Differentiation Anatomical Structure Morphogenesis Transcription Regulator Complex Axonemal A Tubule Inner Sheath Embryonic Morphogenesis Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Neuron Differentiation System Development Pituitary Gland Development Muscle Tissue Morphogenesis Adenohypophysis Development	Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process
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