KRTAP19-7 and COL8A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP19-7	COL8A1
Description		keratin associated protein 19-7	collagen type VIII alpha 1 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process		Angiogenesis Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Camera-type Eye Morphogenesis
Pathways		Keratinization	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS			A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 20385826) Axial length ( 24144296) Childhood ear infection ( 27182965) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 28073927 31798171 25631615) Optic disc area ( 28073927 31798171) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 28073927 31798171 25241763) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		83 interacting genes: ANKS1A ARID5A ARMC7 ATPAF2 ATXN1L BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC24 CCNK COL8A1 CYSRT1 DAB1 DAZAP2 DTX2 EVX2 FAM168A FOXD2 FOXH1 FOXI1 GLIS2 GNE GSX1 HOMER3 HOXA1 HSF4 IRX6 KPRP KRT34 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP26-1 KRTAP3-3 KRTAP6-3 KRTAP9-2 LONRF1 MAPK1IP1L MGAT5B MKRN3 NAF1 NEU4 NOTO NOXA1 OTX1 PATZ1 PAX7 PITX1 PITX2 PLSCR3 PLSCR4 POU2AF1 POU4F2 PROP1 PRR13 PSMB1 PSMB2 RBPMS RBPMS2 RHOXF2 RNF44 ROR2 SMN1 SMN2 SPAG8 SPMIP9 TCAP TCF7L2 TEKT5 TFAP2D TLE5 TLX3 TNIP1 TOLLIP TPRX1 VAC14 VENTX VGLL3 VPS37C ZIC1	78 interacting genes: ACTMAP ADAMTSL4 ARMC5 BPIFA1 C22orf39 CCN3 CEP55 CFAP68 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPMIP6 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1
Entrez ID		337974	1295
HPRD ID		11211	00372
Ensembl ID		ENSG00000244362	ENSG00000144810
Uniprot IDs		Q3SYF9	P27658
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Sequence-specific DNA Binding Keratin Filament Identical Protein Binding Nucleus Cellular Developmental Process Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Developmental Process Regionalization Myoblast Fate Commitment Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Biosynthetic Process Pattern Specification Process Somatotropin Secreting Cell Differentiation Anatomical Structure Morphogenesis Transcription Regulator Complex Axonemal A Tubule Inner Sheath Embryonic Morphogenesis Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Neuron Differentiation System Development Pituitary Gland Development Muscle Tissue Morphogenesis Adenohypophysis Development	Intermediate Filament Keratin Filament Identical Protein Binding Collagen Binding Involved In Cell-matrix Adhesion Cytosol Structural Constituent Of Skin Epidermis
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