COL25A1

Description		collagen type XXV alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding
	Biological Process	Axonogenesis Involved In Innervation
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Collagen chain trimerization
Drugs
Diseases
GWAS		Body mass index ( 25133637) Carotid plaque burden ( 28282560) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Height ( 28552196) Late-onset Alzheimer's disease ( 27770636) Schizophrenia (age at onset) ( 21688384) Systemic lupus erythematosus ( 21408207)
Interacting Genes		3 interacting genes: APP IAPP SNCA
Entrez ID		84570
HPRD ID		09886
Ensembl ID		ENSG00000188517
Uniprot IDs		A0A2R8Y760 A8MWQ5 Q9BXS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Protein Complex Oligomerization Regulation Of Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Positive Regulation Of CAMP/PKA Signal Transduction Inclusion Body Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Microglial Cell Activation Response To Copper Ion Regulation Of Supramolecular Fiber Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of CAMP/PKA Signal Transduction Supramolecular Fiber Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Cell-cell Signaling Macrophage Activation Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Cell Communication Adult Locomotory Behavior Response To Interleukin-1 Protein Tetramerization Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Apoptotic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Receptor Ligand Activity Myeloid Leukocyte Activation Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Positive Regulation Of Synaptic Transmission
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