GGT7 and LNPEP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GGT7	LNPEP
Description		gamma-glutamyltransferase 7	leucyl and cystinyl aminopeptidase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Lysosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Leukotriene D4 Biosynthetic Process Negative Regulation Of Response To Oxidative Stress	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Neuropeptide Catabolic Process Protein Catabolic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME	Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		12 interacting genes: CLDN19 CMTM7 CYB561 GPR25 HTR4 LNPEP MALL MTNR1B SLC35A4 TLCD3A TMEM242 TSPO2	37 interacting genes: AGT AQP6 ASGR2 BIK CD79A CGRRF1 CTAG1A CTAG1B CYB5R3 FAM210B FATE1 FCER1G FHOD1 FKBP7 GGT7 GPR42 GPX8 LCN2 LHFPL5 MMGT1 REEP4 REL SLC10A1 SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A
Entrez ID		2686	4012
HPRD ID		07488	01041
Ensembl ID		ENSG00000131067	ENSG00000113441
Uniprot IDs		A0PJJ9 Q9UJ14	Q9UIQ6
PDB IDs			4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6 7ZYF 8CGP 8CGW 8P0I
Enriched GO Terms of Interacting Partners?		Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Large Intestinal Transit Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity	Membrane Positive Regulation Of Telomere Capping
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