GGT7 and TMEM242

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GGT7	TMEM242
Gene Name		gamma-glutamyltransferase 7	transmembrane protein 242
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane	Integral Component Of Membrane
	Molecular Function	Gamma-glutamyltransferase Activity Glutathione Hydrolase Activity
	Biological Process	Proteolysis Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FAM57A GPR25 LHFPL5 MALL TMEM242	3 interactors: GGT7 RNF5 VKORC1
Entrez ID		2686	729515
HPRD ID		07488
Ensembl ID		ENSG00000131067	ENSG00000215712
Uniprot IDs		A0PJJ9 Q9UJ14	Q9NWH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Auditory Receptor Cell Stereocilium Organization Auditory Receptor Cell Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Auditory Receptor Cell Development Inner Ear Receptor Stereocilium Organization Auditory Receptor Cell Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Hair Cell Differentiation Inner Ear Receptor Cell Development Detection Of Mechanical Stimulus Inner Ear Receptor Cell Differentiation	ER-associated Misfolded Protein Catabolic Process Vitamin K Metabolic Process Peptidyl-glutamic Acid Carboxylation Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Regulation Of Autophagic Vacuole Assembly Response To Misfolded Protein Regulation Of Vacuole Organization Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Protein Destabilization Peptide Biosynthetic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagy Leukotriene Metabolic Process Protein K48-linked Ubiquitination Quinone Metabolic Process Drug Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Glutathione Metabolic Process Cellular Ketone Metabolic Process Proteolysis Icosanoid Metabolic Process Protein Metabolic Process Unsaturated Fatty Acid Metabolic Process Regulation Of Autophagy Cellular Response To Topologically Incorrect Protein Vitamin Metabolic Process Fatty Acid Biosynthetic Process Regulation Of Protein Stability
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