HTR1D and S1PR1

Number of citations of the paper that reports this interaction (PMID 11854302)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HTR1D	S1PR1
Gene Name		5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	sphingosine-1-phosphate receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft
	Molecular Function	Serotonin Receptor Activity Serotonin Binding	G-protein Coupled Receptor Binding G-protein Coupled Receptor Activity Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Response To Toxic Substance Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Signaling Pathway Chemotaxis Cell Adhesion G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Brain Development Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Actin Cytoskeleton Reorganization Positive Regulation Of Ras GTPase Activity Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs		Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Lisuride Sumatriptan Ergotamine Apomorphine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Yohimbine
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		3 interactors: HTR1A HTR1B S1PR1	8 interactors: AKT1 CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB
Entrez ID		3352	1901
HPRD ID		01636	03578
Ensembl ID		ENSG00000179546	ENSG00000170989
Uniprot IDs		P28221	P21453
PDB IDs			3V2W 3V2Y
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Serotonin Receptor Signaling Pathway Vasoconstriction Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Anion Transport G-protein Coupled Receptor Signaling Pathway Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cellular Response To Temperature Stimulus Growth Involved In Heart Morphogenesis Negative Regulation Of Serotonin Secretion Blood Circulation Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Sphingosine-1-phosphate Signaling Pathway Negative Regulation Of Stress Fiber Assembly G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Serotonin Metabolic Process Blood Vessel Maturation Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway T Cell Migration Regulation Of Dopamine Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Dopamine Secretion Exploration Behavior Heart Trabecula Morphogenesis Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cell Proliferation Lymphocyte Migration Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Cardiac Muscle Tissue Growth Regulation Of Bone Resorption Regulation Of Synaptic Transmission, GABAergic Behavioral Fear Response Response To Mineralocorticoid Fear Response Cellular Response To Alkaloid	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vasoconstriction G-protein Coupled Receptor Signaling Pathway Wound Healing Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Coagulation Hemostasis Serotonin Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Regulation Of Ion Transport Regulation Of Behavior Platelet Activation Positive Regulation Of Ion Transport Vesicle Organization Signal Transduction Nitric Oxide Metabolic Process Positive Regulation Of Vasoconstriction Response To Hyperoxia Reactive Nitrogen Species Metabolic Process Response To Fluid Shear Stress Signaling Regulation Of Nitric-oxide Synthase Activity Cell Communication Membrane Organization Response To Stress Regulation Of Lipid Metabolic Process Blood Circulation Response To Hormone Negative Regulation Of Ion Transmembrane Transport Vesicle Fusion Negative Regulation Of Transmembrane Transport Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Stimulus Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Ion Transmembrane Transport T Cell Costimulation Regulation Of Oxidoreductase Activity Organelle Fusion Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?			148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Difference) ?			148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Intersection) ?