HTR1D

Gene Name		5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Serotonin Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Response To Toxic Substance Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Lisuride Sumatriptan Ergotamine Apomorphine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Yohimbine
Diseases
GWAS		Height ( 20881960)
Protein-protein Interactions		3 interactors: HTR1A HTR1B S1PR1
Entrez ID		3352
HPRD ID		01636
Ensembl ID		ENSG00000179546
Uniprot IDs		P28221
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Serotonin Receptor Signaling Pathway Vasoconstriction Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Anion Transport G-protein Coupled Receptor Signaling Pathway Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cellular Response To Temperature Stimulus Growth Involved In Heart Morphogenesis Negative Regulation Of Serotonin Secretion Blood Circulation Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Sphingosine-1-phosphate Signaling Pathway Negative Regulation Of Stress Fiber Assembly G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Serotonin Metabolic Process Blood Vessel Maturation Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway T Cell Migration Regulation Of Dopamine Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Dopamine Secretion Exploration Behavior Heart Trabecula Morphogenesis Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cell Proliferation Lymphocyte Migration Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Cardiac Muscle Tissue Growth Regulation Of Bone Resorption Regulation Of Synaptic Transmission, GABAergic Behavioral Fear Response Response To Mineralocorticoid Fear Response Cellular Response To Alkaloid
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