HTR1D

Description		5-hydroxytryptamine receptor 1D
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Fenfluramine Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Almotriptan Oxymetazoline Naratriptan Rizatriptan Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Yohimbine Lofexidine NXN-188 Setiptiline Dihydroergocornine Gilteritinib Lecozotan Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Height ( 20881960 28552196) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: HTR1A HTR1B S1PR1
Entrez ID		3352
HPRD ID		01636
Ensembl ID		ENSG00000179546
Uniprot IDs		P28221
PDB IDs		7E32
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Gi/o-coupled Serotonin Receptor Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Binding Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Proliferation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Regulation Of Smooth Muscle Cell Proliferation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Serotonergic Synapse Negative Regulation Of Serotonin Secretion Sphingolipid Binding Growth Involved In Heart Morphogenesis System Process Vascular Process In Circulatory System Receptor-receptor Interaction G Protein-coupled Serotonin Receptor Complex Regulation Of Cell Population Proliferation Chemical Synaptic Transmission Circulatory System Process Trans-synaptic Signaling Blood Vessel Maturation Synaptic Signaling Phospholipase C-activating Serotonin Receptor Signaling Pathway Sphingosine-1-phosphate Receptor Activity Regulation Of Monoatomic Ion Transport Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Dendrite Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Bone Remodeling Regulation Of Secretion By Cell Heart Trabecula Morphogenesis Regulation Of Dopamine Metabolic Process Cell-cell Signaling
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