HTR1D and HTR1B

Number of citations of the paper that reports this interaction (PMID 11854302)
10

Data Source:
HPRD (in vivo)

		HTR1D	HTR1B
Gene Name		5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Serotonin Binding	Serotonin Receptor Activity Drug Binding Serotonin Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Response To Toxic Substance Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior	G-protein Coupled Receptor Internalization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Synaptic Transmission, GABAergic Cellular Response To Drug Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Temperature Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Lisuride Sumatriptan Ergotamine Apomorphine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Yohimbine	Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Yohimbine Asenapine Bopindolol
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		3 interactors: HTR1A HTR1B S1PR1	3 interactors: HTR1A HTR1D MDFI
Entrez ID		3352	3351
HPRD ID		01636	01634
Ensembl ID		ENSG00000179546
Uniprot IDs		P28221	P28222
PDB IDs			2G1X 4IAQ 4IAR
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Serotonin Receptor Signaling Pathway Vasoconstriction Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Anion Transport G-protein Coupled Receptor Signaling Pathway Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cellular Response To Temperature Stimulus Growth Involved In Heart Morphogenesis Negative Regulation Of Serotonin Secretion Blood Circulation Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Sphingosine-1-phosphate Signaling Pathway Negative Regulation Of Stress Fiber Assembly G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Serotonin Metabolic Process Blood Vessel Maturation Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway T Cell Migration Regulation Of Dopamine Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Dopamine Secretion Exploration Behavior Heart Trabecula Morphogenesis Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cell Proliferation Lymphocyte Migration Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Cardiac Muscle Tissue Growth Regulation Of Bone Resorption Regulation Of Synaptic Transmission, GABAergic Behavioral Fear Response Response To Mineralocorticoid Fear Response Cellular Response To Alkaloid	Serotonin Receptor Signaling Pathway Vasoconstriction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Intestine Smooth Muscle Contraction Blood Circulation Regulation Of Serotonin Secretion Serotonin Metabolic Process Trophoblast Giant Cell Differentiation Regulation Of Dopamine Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Cytoplasmic Sequestering Of Protein Exploration Behavior Cell Differentiation Involved In Embryonic Placenta Development Behavioral Fear Response Activation Of JUN Kinase Activity Fear Response Negative Regulation Of DNA Binding Regulation Of Cellular Localization Negative Regulation Of Transcription Factor Import Into Nucleus G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Positive Regulation Of JUN Kinase Activity Negative Regulation Of Protein Import Into Nucleus Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Signal Transduction Negative Regulation Of Intracellular Protein Transport Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding Phenol-containing Compound Metabolic Process Signaling Axis Specification Cell Communication Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis
Tagcloud ?			1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?			1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
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