HTR1D and HTR1A

Number of citations of the paper that reports this interaction (PMID 11854302)
10

Data Source:
HPRD (in vitro, in vivo)

		HTR1D	HTR1A
Gene Name		5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Serotonin Binding	Serotonin Receptor Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Response To Toxic Substance Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior	Behavioral Fear Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Lisuride Sumatriptan Ergotamine Apomorphine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Yohimbine	Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Pramipexole Chlorpromazine Buspirone Nortriptyline Propranolol Lisuride Trazodone Sumatriptan Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Iloperidone Rotigotine Asenapine Vilazodone Bopindolol Cinitapride Lurasidone
Diseases
GWAS		Height ( 20881960)	Alcohol and nictotine co-dependence ( 23216389) Body mass index ( 20935630)
Protein-Protein Interactions		3 interactors: HTR1A HTR1B S1PR1	7 interactors: GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		3352	3350
HPRD ID		01636	00190
Ensembl ID		ENSG00000179546
Uniprot IDs		P28221	A8K5W4 P08908 Q5ZGX3
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Serotonin Receptor Signaling Pathway Vasoconstriction Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Anion Transport G-protein Coupled Receptor Signaling Pathway Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cellular Response To Temperature Stimulus Growth Involved In Heart Morphogenesis Negative Regulation Of Serotonin Secretion Blood Circulation Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Sphingosine-1-phosphate Signaling Pathway Negative Regulation Of Stress Fiber Assembly G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Serotonin Metabolic Process Blood Vessel Maturation Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway T Cell Migration Regulation Of Dopamine Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Dopamine Secretion Exploration Behavior Heart Trabecula Morphogenesis Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cell Proliferation Lymphocyte Migration Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Cardiac Muscle Tissue Growth Regulation Of Bone Resorption Regulation Of Synaptic Transmission, GABAergic Behavioral Fear Response Response To Mineralocorticoid Fear Response Cellular Response To Alkaloid	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Sphingosine-1-phosphate Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Regulation Of Behavior Negative Regulation Of Lyase Activity Signal Transduction Vasoconstriction Signaling Cell Communication Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Cellular Response To Stimulus Regulation Of Cyclase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Negative Regulation Of Establishment Of Endothelial Barrier Cellular Response To Temperature Stimulus Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stimulus Growth Involved In Heart Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Serotonin Secretion Intestine Smooth Muscle Contraction Cytosolic Calcium Ion Homeostasis Negative Regulation Of Endothelial Cell Differentiation Regulation Of Serotonin Secretion Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Cellular Calcium Ion Homeostasis Negative Regulation Of Stress Fiber Assembly Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Blood Vessel Maturation Negative Regulation Of Synaptic Transmission, Glutamatergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Tagcloud ?			analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter
Tagcloud (Difference) ?			analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter
Tagcloud (Intersection) ?