GSPT1 and USP15

Number of citations of the paper that reports this interaction (PubMedID 34583995)
82

Data Source:
BioGRID (enzymatic study)

		GSPT1	USP15
Description		G1 to S phase transition 1	ubiquitin specific peptidase 15
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Catalytic Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin-modified Histone Reader Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		13 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CEBPA CRBN ETF1 GSPT2 HINFP PABPC1 PIK3R1 USP15 XIAP	61 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDC73 CSNK1A1 FHL1 GEMIN4 GLUL GOLGA2 GOLGA6A GSPT1 H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PARP1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RIGI RNF126 RNF144B RNF26 SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		2935	9958
HPRD ID		00753	05293
Ensembl ID		ENSG00000103342	ENSG00000135655
Uniprot IDs		B2RCT6 P15170 Q7KZX8	Q9Y4E8
PDB IDs		3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT 6XK9	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1 7R2G
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of RIG-I Signaling Pathway RNA Metabolic Process Translation Release Factor Complex Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Activity Regulation Of Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Canonical NF-kappaB Signal Transduction DNA-templated Transcription Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleic Acid Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Translational Termination Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Signal Transduction Nucleus Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Immune System Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Hemopoiesis Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Necrotic Cell Death Cytosol MRNA Catabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Poly(U) RNA Binding Positive Regulation Of Protein Modification Process Positive Regulation Of RNA Metabolic Process	Post-translational Protein Modification Protein Modification Process Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Cysteine-type Peptidase Activity Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Peptidase Activity Protein K48-linked Deubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity DeNEDDylase Activity Catabolic Process Zinc Ion Binding Cytosol Protein Polyubiquitination Proteasomal Protein Catabolic Process Cytoplasm Deubiquitinase Activity Protein Catabolic Process Innate Immune Response Ubiquitin Binding Cysteine-type Endopeptidase Activity Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Transferase Activity Defense Response To Symbiont Metal Ion Binding Defense Response To Other Organism Response To External Biotic Stimulus Response To Stress Response To Other Organism Hydrolase Activity Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Regulation Of Signal Transduction Antiviral Innate Immune Response Regulation Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Regulation Of Double-strand Break Repair
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