GSPT1 and BIRC3

Number of citations: 33 (PubMedID 30948266)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		GSPT1	BIRC3
Name		G1 to S phase transition 1	baculoviral IAP repeat containing 3
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly	Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Spermatogenesis Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs		Guanosine-5'-Diphosphate	None
GWAS		Height ( 28552196 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Menopause (age at onset) ( 26414677 ) Red blood cell count ( 32888494 ) Testicular germ cell tumor ( 26503584 )	Prostate cancer ( 23535732 ) Whole-brain volume (Alzheimer's disease interaction) ( 21116278 )
Interacting Genes		13 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CEBPA CRBN ETF1 GSPT2 HINFP PABPC1 PIK3R1 USP15 XIAP	37 interacting genes: BIRC5 CASP3 CASP7 CASP9 CD40 CTBP2 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1
Entrez ID		2935	330
HPRD ID		00753	03426
Ensembl ID		ENSG00000103342	ENSG00000023445
Uniprot IDs		B2RCT6 P15170 Q7KZX8	Q13489
PDB IDs		3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT 6XK9	2UVL 3EB5 3EB6 3M0A 3M0D 7NK0
GO Terms Enriched among Interactors		Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of RIG-I Signaling Pathway RNA Metabolic Process Translation Release Factor Complex Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Activity Regulation Of Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Canonical NF-kappaB Signal Transduction DNA-templated Transcription Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleic Acid Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Translational Termination Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Signal Transduction Nucleus Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Immune System Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Hemopoiesis Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Necrotic Cell Death Cytosol MRNA Catabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Poly(U) RNA Binding Positive Regulation Of Protein Modification Process Positive Regulation Of RNA Metabolic Process	Post-translational Protein Modification Protein Modification Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity CD40 Receptor Complex Protein Polyubiquitination Proteolysis Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Catabolic Process Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Post-translational Protein Modification Apoptotic Signaling Pathway Protein Catabolic Process DNA Damage Response Regulation Of Metabolic Process Regulation Of Programmed Cell Death Fibroblast Apoptotic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Response To Stress Intrinsic Apoptotic Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Neuron Apoptotic Process Regulation Of Signal Transduction