HSBP1 and KIAA1217

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		HSBP1	KIAA1217
Name		heat shock factor binding protein 1	KIAA1217
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Axon Cytoplasm	Cytoplasm Centrosome Cytoskeleton
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Axonal Transport Of Mitochondrion Endodermal Cell Differentiation Cellular Heat Acclimation	Embryonic Skeletal System Development
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	None
GWAS		Lead levels ( 26025379 ) Metabolite levels ( 23823483 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872 )	Breast cancer and/or colorectal cancer ( 29698419 ) Cognitive function in longevity ( 33607172 ) Cognitive performance ( 20125193 ) Coronary artery disease ( 29212778 ) Diverticular disease ( 30177863 ) Haemorrhoidal disease ( 33888516 ) Homeostasis model assessment of insulin resistance ( 33381925 ) Lobe attachment (rater scored) ( 29198719 ) Lobe attachment (rater-scored or self-reported) ( 29198719 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Obesity (early onset extreme) ( 23563609 ) Schizophrenia ( 30285260 ) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770 ) Triglyceride levels x loop diuretics use interaction ( 31806883 )
Novel Interactors		4 novel interactors: CD1B MPHOSPH6 RPL13 SDR42E1	None recorded
Interacting Genes		20 interacting genes: BLOC1S5 CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPP7 NOTCH2NLA SDCBP SDCBP2 UBC WASHC1 WASHC3 ZBTB25	23 interacting genes: ABI1 ABI2 ALKBH7 EXOC8 EXOSC5 FHL2 FXR2 GCC1 GOLGA2 HSBP1 INCA1 KRT15 KRT27 KRT31 NCK2 PTK6 RINT1 SIAH1 SORBS3 TEX11 TRAF1 TRAF2 VPS52
Entrez ID		3281	56243
HPRD ID		05185	11132
Ensembl ID		ENSG00000230989	ENSG00000120549
Uniprot IDs		O75506	B7ZM29 Q5T5P2
PDB IDs		3CI9	Not available
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein WASH Complex Cellular Response To Unfolded Protein Regulation Of Inclusion Body Assembly	Signaling Adaptor Activity Supramolecular Fiber Organization Cytosol Identical Protein Binding Positive Regulation Of Apoptotic Signaling Pathway Actin-based Cell Projection Structural Constituent Of Skin Epidermis Thioesterase Binding SCAR Complex Intermediate Filament Organization Regulation Of Apoptotic Signaling Pathway Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Protein Kinase Activity Filopodium Tip Structural Constituent Of Cytoskeleton Regulation Of Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Cytoskeletal Anchor Activity Golgi Vesicle Transport Tumor Necrosis Factor Receptor Binding Cytoplasm Regulation Of Protein Modification Process Intermediate Filament Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Vesicle Membrane Meiotic Gene Conversion Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Protein Phosphorylation Lamellipodium Organization Structural Molecule Activity Negative Regulation Of Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Syntaxin Binding Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Atrial Cardiac Muscle Cell Development Cellular Developmental Process Cytoskeleton Regulation Of Phosphorylation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Actin Polymerization Or Depolymerization Zonula Adherens Assembly