HSBP1 and CD1B

		HSBP1	CD1B
Description		heat shock factor binding protein 1	CD1b molecule
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Axon Cytoplasm	Extracellular Space Lysosome Lysosomal Membrane Endosome Golgi Apparatus Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Lipopeptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Axonal Transport Of Mitochondrion Endodermal Cell Differentiation Cellular Heat Acclimation	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Lead levels ( 26025379) Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		20 interacting genes: BLOC1S5 CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPP7 NOTCH2NLA SDCBP SDCBP2 UBC WASHC1 WASHC3 ZBTB25	2 interacting genes: B2M PSAP
Entrez ID		3281	910
HPRD ID		05185	01775
Ensembl ID		ENSG00000230989	ENSG00000158485
Uniprot IDs		O75506	P29016
PDB IDs		3CI9	1GZP 1GZQ 1UQS 2H26 3OV6 3T8X 4ONO 5C9J 5L2J 5L2K 5WKE 5WKG 5WKI 5WL1 6CUG 6D64 8DV3 8DV4 8GLE 8GLF 8GLG 8GLH 8GLI 8ZOX
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein WASH Complex Cellular Response To Unfolded Protein Regulation Of Inclusion Body Assembly	Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Cellular Response To Iron(III) Ion Negative Regulation Of Forebrain Neuron Differentiation Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Negative Regulation Of Iron Ion Transport Ganglioside GT1b Binding Ganglioside GM1 Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Regulation Of Forebrain Neuron Differentiation Response To Iron(III) Ion Cellular Response To Nicotine HFE-transferrin Receptor Complex Regulation Of Iron Ion Transport MHC Class I Peptide Loading Complex Lysosomal Membrane Cellular Response To Iron Ion Early Endosome Lumen Identical Protein Binding Cellular Heat Acclimation Glycolipid Transport MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Epithelial Cell Differentiation Involved In Prostate Gland Development Prostate Gland Growth Transferrin Transport Peptide Antigen Assembly With MHC Class II Protein Complex Cell Differentiation Axonal Transport Of Mitochondrion Positive Regulation Of Cellular Senescence MHC Class II Protein Complex Ceramide Transport T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Endogenous Antigen Multicellular Organismal-level Iron Ion Homeostasis Amyloid Fibril Formation Cellular Developmental Process Protein Homodimerization Activity Protein Refolding Mitochondrion Transport Along Microtubule Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Response To Iron Ion
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