HSBP1 and ZBTB25

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HSBP1	ZBTB25
Name		heat shock factor binding protein 1	zinc finger and BTB domain containing 25
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Axon Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Axonal Transport Of Mitochondrion Endodermal Cell Differentiation Cellular Heat Acclimation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	None
GWAS		Lead levels ( 26025379 ) Metabolite levels ( 23823483 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872 )	Heel bone mineral density ( 30598549 ) Lymphocyte count ( 27863252 ) Lymphocyte percentage of white cells ( 27863252 32888494 )
Interacting Genes		20 interacting genes: BLOC1S5 CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPP7 NOTCH2NLA SDCBP SDCBP2 UBC WASHC1 WASHC3 ZBTB25	33 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1
Entrez ID		3281	7597
HPRD ID		05185	01926
Ensembl ID		ENSG00000230989	ENSG00000089775
Uniprot IDs		O75506	G3V2K3 P24278
PDB IDs		3CI9	Not available
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein WASH Complex Cellular Response To Unfolded Protein Regulation Of Inclusion Body Assembly	Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Post-translational Protein Modification CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Regulation Of Protein Deubiquitination Positive Regulation Of Protein Deubiquitination Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II MyD88-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Protein Homooligomerization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Transcription Factor Binding Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Ubiquitin-like Protein Ligase Binding Regulation Of T Cell Mediated Immunity Translesion Synthesis Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAPK Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of T Cell Cytokine Production Protein Complex Oligomerization Arachidonate 5,6-epoxygenase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress TORC2 Complex Disassembly Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Pro-T Cell Differentiation