HEY2 and HAND2

Number of citations of the paper that reports this interaction (PubMedID 10924525)
36

Data Source:
HPRD (in vitro, two hybrid)

		HEY2	HAND2
Description		hes related family bHLH transcription factor with YRPW motif 2	heart and neural crest derivatives expressed 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Hypertrophy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Pattern Specification Process Heart Development Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation By RNA Polymerase II Labyrinthine Layer Blood Vessel Development Blood Vessel Endothelial Cell Differentiation Artery Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Differentiation Regulation Of Tissue Remodeling Norepinephrine Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Embryonic Skeletal System Development Peripheral Nervous System Neuron Development Roof Of Mouth Development Mesenchyme Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Determination Of Heart Left/right Asymmetry Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Positive Regulation Of P38MAPK Cascade Primary Palate Development Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis	Transcriptional regulation by RUNX2 Cardiogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 35210625 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)	Atrial fibrillation ( 28416822 29892015 30061737 33990960) Chin dimples ( 27182965) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) PR interval ( 32439900)
Interacting Genes		27 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4	19 interacting genes: CENPB COPS5 DNMT3L EP300 FAM90A1 GATA4 HAND1 HEY2 HEYL KANK2 NPM1 PHOX2A PPP2R5D PRKACA PRKCA RIPPLY1 SPANXN3 TCF3 USP20
Entrez ID		23493	9464
HPRD ID		05243	03872
Ensembl ID		ENSG00000135547	ENSG00000164107
Uniprot IDs		Q5TF93 Q9UBP5	P61296
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis HLH Domain Binding Cardiac Right Ventricle Formation Keratin Filament Chromatin Regulation Of Transcription By RNA Polymerase II Cytosol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Identical Protein Binding Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Heart Left/right Asymmetry Transcription Corepressor Binding Cardiac Ventricle Formation Negative Regulation Of Transcription By RNA Polymerase II Cartilage Morphogenesis E-box Binding Regulation Of Cardioblast Proliferation Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Artery Morphogenesis Cardiac Chamber Formation Protein Dimerization Activity Regulation Of Cellular Response To Growth Factor Stimulus DNA Binding Protein Deacetylation Protein Lysine Deacetylase Activity Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Septum Morphogenesis Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription By RNA Polymerase II Atrioventricular Valve Formation Mesenchymal Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Pattern Specification Heart Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Fate Commitment DNA-binding Transcription Factor Binding Protein Dimerization Activity Nucleoplasm DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Cardiac Right Ventricle Morphogenesis Heart Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Nucleus System Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Tissue Development
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