HPX and GLUD1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		HPX	GLUD1
Name		hemopexin	glutamate dehydrogenase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Protein Binding Heme Transmembrane Transporter Activity Metal Ion Binding	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Intracellular Iron Ion Homeostasis Heme Transport Hemoglobin Metabolic Process Heme Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Response To Type II Interferon Type II Interferon-mediated Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process
Pathways		Scavenging of heme from plasma	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation
Drugs		Zinc chloride Zinc sulfate, unspecified form	Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
GWAS		Malaria ( 31844061 )	Renal underexcretion gout ( 32238385 )
Interacting Genes		4 interacting genes: GLUD1 HSP90AA1 LINC02582 TP63	16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN
Entrez ID		3263	2746
HPRD ID		00793	11748
Ensembl ID		ENSG00000110169	ENSG00000148672
Uniprot IDs		P02790 Q9BS19	E9KL48 P00367
PDB IDs		Not available	1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J
GO Terms Enriched among Interactors		Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Rho GDP-dissociation Inhibitor Binding Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Prostatic Bud Formation L-leucine Binding Glutamate Biosynthetic Process L-glutamate Catabolic Process Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Mesoderm Development Negative Regulation Of Keratinocyte Differentiation Morphogenesis Of A Polarized Epithelium Positive Regulation Of Fibroblast Apoptotic Process GTP Binding Positive Regulation Of Cell Size Cardiac Muscle Cell Apoptotic Process Protein Unfolding Positive Regulation Of Striated Muscle Contraction Striated Muscle Cell Apoptotic Process Genitalia Morphogenesis Skin Morphogenesis MDM2/MDM4 Family Protein Binding Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Somatic Stem Cell Population Maintenance	Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation