HPR and APOA1

Number of citations: 47 (PubMedID 10085035)
Data Source: HPRD (in vitro)

		HPR	APOA1
Name		haptoglobin-related protein	apolipoprotein A1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity
	Biological Process	Zymogen Activation	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta
Pathways		Scavenging of heme from plasma	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		Zinc Copper Zinc acetate	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		None	Hypoalphalipoproteinemia Familial amyloidosis
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Cholesterol, total ( 20686565 24097068 25961943 26582766 28270201 ) Coronary artery disease ( 33020668 32469254 ) Hematocrit ( 32888494 ) LDL cholesterol ( 20686565 24097068 25961943 26582766 ) LDL cholesterol levels ( 30698716 28334899 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Metabolite levels ( 22916037 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Allergic rhinitis ( 30013184 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 31978080 ) Cholesterol, total ( 19060911 20686565 24097068 ) Coronary artery disease ( 24262325 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Diastolic blood pressure ( 27841878 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672 ) HDL cholesterol levels ( 28334899 ) Hearing function ( 25060954 ) Hematological and biochemical traits ( 20139978 ) Hypertriglyceridemia ( 27599772 23505323 ) Infantile hypertrophic pyloric stenosis ( 23989729 ) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 24386095 ) Metabolite levels ( 22916037 ) Postprandial triglyceride levels ( 32603185 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels ( 28334899 32759990 ) Total triglycerides levels ( 26690388 ) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990 ) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043 ) Very low density lipoprotein cholesterol levels ( 28548082 )
Interacting Genes		4 interacting genes: APOA1 HSP90AA1 IGHM VKORC1	38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF
Entrez ID		3250	335
HPRD ID		00773	02517
Ensembl ID		ENSG00000261701	ENSG00000118137
Uniprot IDs		P00739	A0A024R3E3 P02647
PDB IDs		Not available	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS
GO Terms Enriched among Interactors		Endocytic Vesicle Lumen Blood Microparticle Secretory Granule Lumen CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Intracellular Transport Rho GDP-dissociation Inhibitor Binding IgM B Cell Receptor Complex Apolipoprotein A-I Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Spherical High-density Lipoprotein Particle Protein Stabilization Regulation Of Intestinal Cholesterol Absorption Lipoprotein Particle Binding High-density Lipoprotein Particle Clearance Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Regulation Of Intracellular Transport Quinone Binding	High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport