HPR

Name	haptoglobin-related protein
Structure	No pdb structure
Novel Interactors	2 novel interactors: DYNC1LI2 PSKH1
Interactors	4 interactors: APOA1 HSP90AA1 IGHM VKORC1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding
	Biological Process	Zymogen Activation
Pathways	Scavenging of heme from plasma
Drugs	Zinc Copper Zinc acetate
GWAS	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Cholesterol, total ( 20686565 24097068 25961943 26582766 28270201 ) Coronary artery disease ( 33020668 32469254 ) Hematocrit ( 32888494 ) LDL cholesterol ( 20686565 24097068 25961943 26582766 ) LDL cholesterol levels ( 30698716 28334899 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Metabolite levels ( 22916037 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Entrez ID	3250
HPRD ID	00773
Ensembl ID	ENSG00000261701
Uniprot IDs	P00739
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Endocytic Vesicle Lumen Blood Microparticle Secretory Granule Lumen CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Intracellular Transport Rho GDP-dissociation Inhibitor Binding IgM B Cell Receptor Complex Apolipoprotein A-I Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Spherical High-density Lipoprotein Particle Protein Stabilization Regulation Of Intestinal Cholesterol Absorption Lipoprotein Particle Binding High-density Lipoprotein Particle Clearance Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Regulation Of Intracellular Transport Quinone Binding