HPR

Description		haptoglobin-related protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding
	Biological Process	Zymogen Activation
Pathways		Scavenging of heme from plasma
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874 33547301) Cholesterol, total ( 20686565 24097068 25961943 26582766 28270201) Coronary artery disease ( 33020668 32469254) Hematocrit ( 32888494) LDL cholesterol ( 20686565 24097068 25961943 26582766) LDL cholesterol levels ( 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Novel Interacting Genes		2 novel interacting genes: DYNC1LI2 PSKH1
Interacting Genes		4 interacting genes: APOA1 HSP90AA1 IGHM VKORC1
Entrez ID		3250
HPRD ID		00773
Ensembl ID		ENSG00000261701
Uniprot IDs		P00739
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Lumen Blood Microparticle Secretory Granule Lumen CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Intracellular Transport Rho GDP-dissociation Inhibitor Binding IgM B Cell Receptor Complex Apolipoprotein A-I Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Spherical High-density Lipoprotein Particle Protein Stabilization Regulation Of Intestinal Cholesterol Absorption Lipoprotein Particle Binding High-density Lipoprotein Particle Clearance Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Regulation Of Intracellular Transport Quinone Binding
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