HPR and DYNC1LI2

Data Source: HiPPIP (Novel)

		HPR	DYNC1LI2
Name		haptoglobin-related protein	dynein cytoplasmic 1 light intermediate chain 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle	Kinetochore Cytoplasm Late Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Membrane Dynein Complex
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding	Nucleotide Binding ATP Binding Identical Protein Binding Dynein Heavy Chain Binding
	Biological Process	Zymogen Activation	Microtubule Cytoskeleton Organization Microtubule-based Movement Positive Regulation Of Intracellular Transport Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus
Pathways		Scavenging of heme from plasma	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Zinc Copper Zinc acetate	None
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Cholesterol, total ( 20686565 24097068 25961943 26582766 28270201 ) Coronary artery disease ( 33020668 32469254 ) Hematocrit ( 32888494 ) LDL cholesterol ( 20686565 24097068 25961943 26582766 ) LDL cholesterol levels ( 30698716 28334899 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Metabolite levels ( 22916037 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Lipid traits ( 30576415 )
Novel Interactors		2 novel interactors: DYNC1LI2 PSKH1	4 novel interactors: CTRL FCSK HPR ZFHX3
Interacting Genes		4 interacting genes: APOA1 HSP90AA1 IGHM VKORC1	6 interacting genes: APP BRCA2 DMTN GAA LINC00632 OGT
Entrez ID		3250	1783
HPRD ID		00773	09923
Ensembl ID		ENSG00000261701	ENSG00000135720
Uniprot IDs		P00739	O43237
PDB IDs		Not available	6F1T 6F1Y 6F38 6F3A 7Z8F 7Z8I 7Z8J 7Z8K 7Z8L 8PR0 8PR1 8PR2 8PR3 8PTK
GO Terms Enriched among Interactors		Endocytic Vesicle Lumen Blood Microparticle Secretory Granule Lumen CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Intracellular Transport Rho GDP-dissociation Inhibitor Binding IgM B Cell Receptor Complex Apolipoprotein A-I Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Spherical High-density Lipoprotein Particle Protein Stabilization Regulation Of Intestinal Cholesterol Absorption Lipoprotein Particle Binding High-density Lipoprotein Particle Clearance Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Regulation Of Intracellular Transport Quinone Binding	Hemopoiesis Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cell Junction Assembly Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Homeostasis Cellular Response To CAMP Cell Development Lipoprotein Particle Positive Regulation Of Protein Import Response To CAMP Circadian Regulation Of Gene Expression Regulation Of Locomotor Rhythm Mitotic Recombination-dependent Replication Fork Processing BRCA2-MAGE-D1 Complex Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Autolysosome Lumen Sucrose Metabolic Process Vacuolar Sequestering Maltose Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Fucokinase Activity GDP-L-fucose Salvage PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Diaphragm Contraction Alpha-1,4-glucosidase Activity Protein O-acetylglucosaminyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle