HPCAL1 and DTX2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HPCAL1	DTX2
Gene Name		hippocalcin-like 1	deltex 2, E3 ubiquitin ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Calcium Ion Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Signal Transduction	Notch Signaling Pathway Protein Ubiquitination
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ATXN1 C1QTNF2 DTX2 HMG20A IKBKG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 NOTCH2NL SLC34A1	41 interactors: ABHD16A ALKBH4 ARNT2 C1orf94 DTX1 DTX3 EIF4ENIF1 FAM168A FHL2 GLYCTK GOLGA2 HDC HPCAL1 HPCAL4 KLC3 KRTAP26-1 MDC1 NCALD NCS1 NOTCH1 PLEKHF2 PLSCR1 QARS RBPMS RFX6 RHOXF2 RIMBP3 SEC22A SEC23B SPAG8 SPG21 STX12 SUMO1 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D3 UBE2D4 UBQLN4 VSNL1
Entrez ID		3241	113878
HPRD ID		02564	16841
Ensembl ID		ENSG00000115756	ENSG00000091073
Uniprot IDs		O75544 P37235 Q6FGY1	Q86UW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport Gentamycin Metabolic Process Indole Metabolic Process Arsenate Ion Transmembrane Transport Cellular Response To Staurosporine Notch Signaling Pathway Activation Of MAPK Activity Regulation Of Sodium-dependent Phosphate Transport Dentinogenesis Regulation Of Phosphate Transport Positive Regulation Of MAP Kinase Activity Cellular Response To Parathyroid Hormone Stimulus Sodium-dependent Phosphate Transport Response To Potassium Ion Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Homooligomerization Activation Of Protein Kinase Activity Regulation Of Membrane Potential Positive Regulation Of Protein Serine/threonine Kinase Activity	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transcription, DNA-templated RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Innate Immune Response Protein K11-linked Ubiquitination RNA Metabolic Process Cellular Response To Oxygen Levels Heart Trabecula Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Hypoxia Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Notch Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Pancreatic Epsilon Cell Differentiation Glutaminyl-tRNA Aminoacylation Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Pancreatic D Cell Differentiation Cleavage Furrow Ingression Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Glandular Epithelial Cell Differentiation Signal Transduction Trabecula Morphogenesis Positive Regulation Of Innate Immune Response Vesicle Fusion Regulation Of Immune System Process Prolyl-tRNA Aminoacylation Vasculogenesis Involved In Coronary Vascular Morphogenesis Cardiac Right Atrium Morphogenesis Mitral Valve Formation Histamine Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		alpha4beta2 antioxidative apoe4 b5 calbindin comparatively d28k dendrites exam explaining gwas hint instance limbic mmse nachr ncs neurofibrillary neuroplasticity nft nicotinergic nicotinic psychosis tangles tie vilip visinin vsnl1 vsnls	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Difference) ?		alpha4beta2 antioxidative apoe4 b5 calbindin comparatively d28k dendrites exam explaining gwas hint instance limbic mmse nachr ncs neurofibrillary neuroplasticity nft nicotinergic nicotinic psychosis tangles tie vilip visinin vsnl1 vsnls	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Intersection) ?