HPCAL1 and MYDGF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HPCAL1	MYDGF
Description		hippocalcin like 1	myeloid derived growth factor
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GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Signal Transduction	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways			XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)
Interacting Genes		39 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 CEBPA COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	13 interacting genes: ACOT13 BAG6 EIF3F HPCA HPCAL1 LCN2 MDM2 NCALD SGTA SGTB UBQLN1 UBQLN2 UBQLN4
Entrez ID		3241	56005
HPRD ID		02564	08415
Ensembl ID		ENSG00000115756	ENSG00000074842
Uniprot IDs		O75544 P37235 Q6FGY1	Q969H8
PDB IDs		5T7C	6O6W 6SVK 6SVL
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Identical Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Targeting To Membrane Regulation Of Receptor Internalization Response To Endoplasmic Reticulum Stress Autophagosome Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Catabolic Process Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Receptor-mediated Endocytosis Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Response To Iron Ion Molecular Adaptor Activity Regulation Of Macroautophagy Protein Targeting Establishment Of Protein Localization To Membrane Regulation Of Protein Metabolic Process Hsp70 Protein Binding
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