HPCAL1 and CA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HPCAL1	CA3
Description		hippocalcin like 1	carbonic anhydrase 3
Image
GO Annotations	Cellular Component	Membrane	Nucleus Cytoplasm Cytosol Sarcomere
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Nickel Cation Binding Phosphatase Activity Lyase Activity Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction	Skeletal Muscle Contraction Response To Oxidative Stress Positive Regulation Of Cell Population Proliferation Response To Bacterium Cellular Response To Insulin Stimulus Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Leptin Stimulus Response To Ethanol Cellular Response To Hypoxia Response To Alcohol Liver Regeneration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Pathways			Reversible hydration of carbon dioxide
Drugs			Topiramate Ethoxzolamide Sulpiride Celecoxib Benzthiazide Valdecoxib Cyclothiazide Methazolamide Acetazolamide Dorzolamide Zonisamide Diclofenamide Brinzolamide Ellagic acid Saccharin
Diseases
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)	Blood protein levels ( 30072576) Blood trace element (Zn levels) ( 23720494) Estimated glomerular filtration rate ( 31152163) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252)
Interacting Genes		39 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 CEBPA COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	3 interacting genes: HPCAL1 LXN SRC
Entrez ID		3241	761
HPRD ID		02564	00260
Ensembl ID		ENSG00000115756	ENSG00000164879
Uniprot IDs		O75544 P37235 Q6FGY1	P07451
PDB IDs		5T7C	1Z93 1Z97 2HFW 3UYN 3UYQ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process	Regulation Of Catalytic Activity G Protein-coupled Glutamate Receptor Signaling Pathway Scaffold Protein Binding Group II Metabotropic Glutamate Receptor Activity Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Bone Resorption Angiotensin-activated Signaling Pathway Negative Regulation Of Hippo Signaling Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Caveolin-mediated Endocytosis Connexin Binding Regulation Of Lamellipodium Morphogenesis Regulation Of Integrin Activation Positive Regulation Of Dephosphorylation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Maturation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Signal Complex Assembly Positive Regulation Of Protein Processing Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitochondrial Depolarization Uterus Development Negative Regulation Of Focal Adhesion Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Neutrophil Activation Response To Platelet-derived Growth Factor Endolysosomal Toll-like Receptor Signaling Pathway Contractile Actin Filament Bundle Assembly Regulation Of Dephosphorylation Stress Fiber Assembly Progesterone Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phospholipase Binding Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Anoikis
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