HPCAL1 and SLC34A1

Number of citations of the paper that reports this interaction (PubMedID 14694264)
0

Data Source:
HPRD (two hybrid)

		HPCAL1	SLC34A1
Description		hippocalcin like 1	solute carrier family 34 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Endosome Cytosol Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Nuclear Speck Brush Border Membrane Vesicle Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity PDZ Domain Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Signal Transduction	Ossification Kidney Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Response To Nutrient Glycoprotein Metabolic Process Response To Xenobiotic Stimulus Response To Lead Ion Cellular Response To Phosphate Starvation Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion Response To Estradiol Response To Vitamin A Phosphate Ion Transmembrane Transport Response To Potassium Ion Indole Metabolic Process Response To Peptide Hormone Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Phosphate Ion Homeostasis Response To Growth Hormone Response To Parathyroid Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Sodium Ion Import Across Plasma Membrane Gentamycin Metabolic Process Response To Peptide Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways			Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism
Drugs
Diseases			Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)	Activated partial thromboplastin time ( 22703881) Asthma ( 32296059) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 20383146 26831199) Creatinine levels ( 28270201 31015462 29403010) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hematocrit ( 29403010) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369 26272126) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 29403010) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		39 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 CEBPA COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	11 interacting genes: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 NHERF1 NHERF2 PDZK1 PEX19 YIF1A
Entrez ID		3241	6569
HPRD ID		02564	08918
Ensembl ID		ENSG00000115756	ENSG00000131183
Uniprot IDs		O75544 P37235 Q6FGY1	Q06495 Q7Z725 Q86VN6
PDB IDs		5T7C
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process	Brush Border Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Phosphatase Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein Localization To Membrane Apical Plasma Membrane Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Microvillus Membrane Cellular Localization Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Protein Localization To Plasma Membrane ATP-dependent Protein Folding Chaperone Protein Folding Positive Regulation Of Nitric Oxide Biosynthetic Process Localization Within Membrane Positive Regulation Of Nitric Oxide Metabolic Process Intracellular Protein Localization Tau Protein Binding Protein Localization To Cell Periphery Protein Stabilization Cellular Response To Heat CTP Binding DATP Binding Protein Folding Chaperone Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Renal Phosphate Ion Absorption Regulation Of Nitric Oxide Biosynthetic Process Membrane Regulation Of Nitric Oxide Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cell Size Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex PDZ Domain Binding Peroxisome Membrane Targeting Sequence Binding
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